Solar Antonieta A, Schmidt Brian L, Jordan Richard C K
Department of Orofacial Sciences, University of California at San Francisco, San Francisco, California 94143-0424, USA.
Cancer. 2009 Jan 1;115(1):75-83. doi: 10.1002/cncr.23974.
Hyalinizing clear cell carcinoma (HCCC) is an uncommon malignant salivary gland tumor that was characterized only recently as a distinct entity. Because of its histologic similarity to several other primary and metastatic tumors and its purported favorable clinical outcome after local resection, it is important to recognize the features of this unusual tumor.
The authors present 8 new, fully characterized cases of HCCC and systematically reviewed 44 other cases of HCCC reported in the English language literature from 1980 to 2008. Historic cases were reviewed, and available data regarding morphology, special stains, demographics, clinical presentation, radiographic findings, management, and outcomes were extracted. Data from the current series were compared with the earlier published literature.
To the best of the authors' knowledge, this was the largest reviewed series of HCCC and included a total of 52 cases. The findings, which included key histologic features, clinical presentation, and outcome, generally were consistent with what was reported previously. However, the current review revealed that 25% of patients reported in the literature had metastatases at initial presentation, including 10 of 44 patients who had metastases to regional lymph nodes and 1 patient who had metastasis to the lung. The authors were unable to identify any specific histologic features that would predict this behavior.
The current results indicated that HCCC is less indolent than was believed previously; therefore, regional lymph node dissection should be considered in conjunction with wide local excision for patients with HCC.
透明细胞癌（HCCC）是一种罕见的涎腺恶性肿瘤，直到最近才被确认为一种独特的实体。由于其组织学特征与其他几种原发性和转移性肿瘤相似，且据称局部切除后临床预后良好，因此识别这种不寻常肿瘤的特征很重要。
作者报告了8例新的、特征明确的HCCC病例，并系统回顾了1980年至2008年英文文献中报道的其他44例HCCC病例。对既往病例进行回顾，并提取有关形态学、特殊染色、人口统计学、临床表现、影像学检查结果、治疗及预后的可用数据。将本系列病例的数据与早期发表的文献进行比较。
据作者所知，这是最大的一组HCCC回顾性研究系列，共纳入52例病例。研究结果包括关键组织学特征、临床表现和预后，总体上与先前报道一致。然而，当前的回顾显示，文献报道的患者中有25%在初次就诊时已发生转移，其中44例中有10例发生区域淋巴结转移，1例发生肺转移。作者未能识别出任何可预测这种情况的特定组织学特征。
目前的结果表明，HCCC的惰性比之前认为的要低；因此，对于HCCC患者，在广泛局部切除的同时应考虑行区域淋巴结清扫。
