Studdiford James, Oppenheim Laura, McCann Edward, Altshuler Marc
Department of Family and Community Medicine, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.
Pharmacotherapy. 2006 Nov;26(11):1658-61. doi: 10.1592/phco.26.11.1658.
A 20-year-old college student developed an immunologic hypersensitivity reaction, erythema multiforme minor, 1-2 weeks after receiving a meningococcal conjugate vaccine. He had no history of erythema multiforme, nor had he received any other vaccine or drug therapy. The temporal relationship between the development of erythema multiforme and the vaccination suggests that the meningitis vaccine probably was the causal agent. The occurrence of this distinct cutaneous reaction, with the potential for a serious complication such as erythema multiforme major or Stevens-Johnson syndrome on rechallenge, should serve as a warning against repeated booster vaccinations in patients who develop reactions such as this one.
一名20岁的大学生在接种脑膜炎球菌结合疫苗1至2周后出现了免疫超敏反应——轻症多形红斑。他既往无多形红斑病史，也未接受过任何其他疫苗或药物治疗。多形红斑的出现与疫苗接种之间的时间关系表明，脑膜炎疫苗可能是病因。这种独特的皮肤反应的发生，以及再次接种时可能出现严重并发症如重症多形红斑或史蒂文斯 - 约翰逊综合征的可能性，应作为对出现此类反应的患者反复进行加强疫苗接种的警示。
