Ramón y Cajal Hospital, Madrid, Spain.
Dermatology. 2010;221(3):197-200. doi: 10.1159/000319852.
The quadrivalent human papillomavirus (qHPV) vaccine, the first vaccine for use in the prevention of cervical cancer and condyloma acuminatum, was approved in June 2006. In 2008, the mass media reported suspected links between the qHPV vaccine and serious adverse events; however, several studies have found that the vaccine is safe and the main adverse events are mild local reactions. Erythema multiforme (EM) is an acute self-limited cutaneous or mucocutaneous syndrome characterized by the abrupt onset of symmetric target lesions. The clinical manifestations and histological features of EM, Stevens-Johnson syndrome and toxic epidermal necrolysis show considerable overlap, and they are classically considered to represent a spectrum of skin disorders. We present a case of EM following qHPV vaccination to review the cutaneous side effects of this vaccine and the possibility of more serious side effects with the administration of booster doses.
四价人乳头瘤病毒（qHPV）疫苗是第一种用于预防宫颈癌和尖锐湿疣的疫苗，于 2006 年 6 月获得批准。2008 年，大众媒体报道了 qHPV 疫苗与严重不良事件之间的疑似关联；然而，几项研究发现该疫苗是安全的，主要的不良反应是轻微的局部反应。多形红斑（EM）是一种急性、自限性的皮肤或黏膜综合征，其特征为突然出现对称的靶形病变。EM、史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症的临床表现和组织学特征有很大的重叠，它们通常被认为是一系列皮肤疾病。我们报告了一例 qHPV 疫苗接种后发生 EM 的病例，以回顾该疫苗的皮肤副作用，并探讨接种加强剂量可能产生更严重副作用的可能性。
