Karunanayaka Prasanna R, Holland Scott K, Schmithorst Vincent J, Solodkin Ana, Chen E Elinor, Szaflarski Jerzy P, Plante Elena
Imaging Research Center, Children's Hospital Medical Center, 3333 Burnet Ave. ML 5031, Cincinnati, OH 45229, USA.
Neuroimage. 2007 Jan 1;34(1):349-60. doi: 10.1016/j.neuroimage.2006.08.028. Epub 2006 Oct 24.
The way humans comprehend narrative speech plays an important part in human development and experience. A group of 313 children with ages 5-18 were subjected to a large-scale functional magnetic resonance imaging (fMRI) study in order to investigate the neural correlates of auditory narrative comprehension. The results were analyzed to investigate the age-related brain activity changes involved in the narrative language comprehension circuitry. We found age-related differences in brain activity which may either reflect changes in local neuroplasticity (of the regions involved) in the developing brain or a more global transformation of brain activity related to neuroplasticity. To investigate this issue, Structural Equation Modeling (SEM) was applied to the results obtained from a group independent component analysis (Schmithorst, V.J., Holland, S.K., et al., 2005. Cognitive modules utilized for narrative comprehension in children: a functional magnetic resonance imaging study. NeuroImage) and the age-related differences were examined in terms of changes in path coefficients between brain regions. The group Independent Component Analysis (ICA) had identified five bilateral task-related components comprising the primary auditory cortex, the mid-superior temporal gyrus, the most posterior aspect of the superior temporal gyrus, the hippocampus, the angular gyrus and the medial aspect of the parietal lobule (precuneus/posterior cingulate). Furthermore, a left-lateralized network (sixth component) was also identified comprising the inferior frontal gyrus (including Broca's area), the inferior parietal lobule, and the medial temporal gyrus. The components (brain regions) for the SEM were identified based on the ICA maps and the results are discussed in light of recent neuroimaging studies corroborating the functional segregation of Broca's and Wernicke's areas and the important role played by the right hemisphere in narrative comprehension. The classical Wernicke-Geschwind (WG) model for speech processing is expanded to a two-route model involving a direct route between Broca's and Wernicke's area and an indirect route involving the parietal lobe.
人类理解叙事性言语的方式在人类发展和体验中起着重要作用。一组313名年龄在5至18岁之间的儿童接受了一项大规模功能性磁共振成像（fMRI）研究，以调查听觉叙事理解的神经关联。对结果进行分析，以研究叙事语言理解电路中与年龄相关的大脑活动变化。我们发现大脑活动存在与年龄相关的差异，这可能反映了发育中大脑局部神经可塑性（所涉及区域的）变化，或者是与神经可塑性相关的大脑活动更全面的转变。为了研究这个问题，结构方程模型（SEM）被应用于从一组独立成分分析中获得的结果（施密霍斯特，V.J.，霍兰德，S.K.等人，2005年。儿童叙事理解所使用的认知模块：一项功能性磁共振成像研究。《神经影像学》），并根据大脑区域之间路径系数的变化来检查与年龄相关的差异。独立成分分析（ICA）识别出了五个双侧任务相关成分，包括初级听觉皮层、颞中回上部、颞上回最后部、海马体、角回和顶叶小叶内侧（楔前叶/后扣带回）。此外，还识别出了一个左侧化网络（第六个成分），包括额下回（包括布洛卡区）、顶下小叶和颞中回。基于ICA图谱确定了用于SEM的成分（大脑区域），并根据最近的神经影像学研究结果进行了讨论，这些研究证实了布洛卡区和韦尼克区的功能分离以及右半球在叙事理解中所起的重要作用。经典的韦尼克 - 杰施温德（WG）言语处理模型扩展为一个双路径模型，涉及布洛卡区和韦尼克区之间的直接路径以及涉及顶叶的间接路径。
