Wendling Daniel, Toussirot Eric, Streit Gérald, Prati Clément
Rheumatology Department, Jean-Minjoz Teaching Hospital, Boulevard Fleming, 25030 Besançon cedex, France.
Joint Bone Spine. 2006 Dec;73(6):655-60. doi: 10.1016/j.jbspin.2006.03.007. Epub 2006 Sep 20.
Scoring systems have been developed for radiographs and magnetic resonance imaging (MRI) in patients with ankylosing spondylitis (AS). Radiographic scores focus on chronic structural alterations, which occur slowly and show little sensitivity to change in the short-term. Recent clinical studies used the modified Stoke ankylosing spondylitis spine score (mSASSS), which evaluates the cervical and lumbar spine. TNF antagonists were found to modify the mSASSS, indirectly supporting a structural effect of these agents. MRI using specific sequences is a potent tool for evaluating inflammation, most notably at the spine. MRI has proved sensitive to change in patients taking TNF antagonists. An outcome measures in rheumatology clinical trials (OMERACT) task force is working on standardizing MRI scores for the spine and sacroiliac joints.
针对强直性脊柱炎（AS）患者，已经开发出了用于X线片和磁共振成像（MRI）的评分系统。X线片评分关注的是慢性结构改变，这种改变进展缓慢，短期内对变化的敏感性较低。近期的临床研究使用了改良斯托克强直性脊柱炎脊柱评分（mSASSS），该评分用于评估颈椎和腰椎。研究发现肿瘤坏死因子拮抗剂可改变mSASSS，这间接支持了这些药物的结构效应。使用特定序列的MRI是评估炎症的有力工具，在脊柱部位尤为明显。MRI已被证明对使用肿瘤坏死因子拮抗剂的患者的变化敏感。风湿病临床试验结果测量（OMERACT）工作组正在致力于规范脊柱和骶髂关节的MRI评分。
