人类免疫缺陷病毒1型感染中最低CD4淋巴细胞计数（CD4最低点）作为当前认知和神经状态的预测指标——夏威夷HIV感染老年队列研究
Lowest ever CD4 lymphocyte count (CD4 nadir) as a predictor of current cognitive and neurological status in human immunodeficiency virus type 1 infection--The Hawaii Aging with HIV Cohort.
作者信息
Valcour Victor, Yee Priscilla, Williams Andrew E, Shiramizu Bruce, Watters Michael, Selnes Ola, Paul Robert, Shikuma Cecilia, Sacktor Ned
机构信息
Hawaii AIDS Clinical Research Program, University of Hawaii, Honolulu, Hawaii, USA.
出版信息
J Neurovirol. 2006 Oct;12(5):387-91. doi: 10.1080/13550280600915339.
Low CD4 lymphocyte count was a marker for neurological disease in human immunodeficiency virus type 1 (HIV-1); but is now less common among patients with access to highly active antiretroviral therapy. In this study, the authors determine the reliability of self-reported CD4 nadir and its predictive value for neurological status. The authors identify a high degree of reliability (r = .90). After adjusting for age, current CD4 count, and duration of HIV-1, CD4 nadir relates to a current diagnosis of HIV-associated dimentia (HAD) (odds ratio [OR]: 1.395 (1.106-1.761), P = .005) and distal symmetric polyneuropathy (DSPN) (OR: 1.479 (1.221-1.769, P < .001).
低CD4淋巴细胞计数曾是1型人类免疫缺陷病毒（HIV-1）神经疾病的一个标志物；但在能够获得高效抗逆转录病毒治疗的患者中，这种情况现在已不那么常见。在本研究中，作者们确定了自我报告的CD4最低点的可靠性及其对神经状态的预测价值。作者们发现其具有高度可靠性（r = 0.90）。在对年龄、当前CD4计数和HIV-1病程进行校正后，CD4最低点与当前HIV相关痴呆（HAD）诊断相关（比值比[OR]：1.395（1.106 - 1.761），P = 0.005）以及远端对称性多发性神经病（DSPN）相关（OR：1.479（1.221 - 1.769），P < 0.001）。
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