Department of Neuroscience, Georgetown University Medical Center, Washington, DC, 20007, USA.
Department of Medicine, Georgetown University Medical Center, Washington, DC, 20057, USA.
J Neurovirol. 2022 Apr;28(2):265-273. doi: 10.1007/s13365-021-01039-y. Epub 2022 Jan 19.
HIV-associated neurocognitive disorders (HAND) remain highly prevalent in people with HIV (PWH). Studies suggested that certain sociodemographic factors are associated with the risk of HAND in PWH. Here we investigated the impact of HIV infection and demographics on functional brain networks. One run of 8.5 min resting state functional MRI (fMRI) data was collected from 101 PWH (41-70 years old) and 40 demographically comparable controls. Functional connectivity (FC) was calculated using average wavelet coherence. The impact of demographic factors on FCs was investigated using canonical correlation analysis (CCA). Wavelet coherence analysis revealed a reduced within-network connectivity in the dorsal somatomotor network (dSMN), along with a reduced between-network connectivity between dSMN and medial temporal lobe (MTL) in PWH (compared to controls). Across all participants, CCA revealed that older age and HIV infection had negative impacts on network connectivity measures (mainly reduced within- and between-network FCs), whereas education had an opposite effect. In addition, being female at birth or a member of a minority ethnic/racial group was also associated with network disruptions. Our data suggested that advanced age and HIV infection are risk factors for functional brain network disruptions, whereas higher educational attainment was linked to better preserved functional network connectivity.
HIV 相关神经认知障碍（HAND）在 HIV 感染者（PWH）中仍然高度流行。研究表明，某些社会人口因素与 PWH 发生 HAND 的风险相关。在这里，我们研究了 HIV 感染和人口统计学因素对功能性大脑网络的影响。从 101 名 PWH（41-70 岁）和 40 名年龄匹配的对照组中收集了一个 8.5 分钟的静息状态功能磁共振成像（fMRI）数据的运行。使用平均小波相干性计算功能连接（FC）。使用典型相关分析（CCA）研究人口统计学因素对 FC 的影响。小波相干分析显示，与对照组相比，PWH 的背侧躯体运动网络（dSMN）内网络连接减少，dSMN 与内侧颞叶（MTL）之间的网络连接减少。在所有参与者中，CCA 显示年龄较大和 HIV 感染对网络连接测量有负面影响（主要是减少内和网络间 FC），而教育则有相反的效果。此外，出生时为女性或属于少数民族/种族群体也与网络中断有关。我们的数据表明，年龄较大和 HIV 感染是功能性大脑网络中断的危险因素，而较高的教育程度与更好地保留功能性网络连接有关。
