新型去氟（6）喹诺酮DX-619的体外抗厌氧活性
In vitro antianaerobic activity of DX-619, a new des-fluoro(6) quinolone.
作者信息
Tanaka Kaori, Mikamo Hiroshige, Nakao Ken'ichi, Watanabe Kunitomo
机构信息
Division of Anaerobe Research, Life Science Research Center, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan.
出版信息
Antimicrob Agents Chemother. 2006 Nov;50(11):3908-13. doi: 10.1128/AAC.00639-06.
Abstract
The in vitro activity of DX-619, a new des-F(6) quinolone, against anaerobic bacteria was evaluated. DX-619 showed potent activity against Bacteroides, Prevotella, Fusobacterium, Micromonas, Actinomyces, and Clostridium spp., with MIC(50)s/MIC(90)s of </=0.03 to 0.25/</=0.03 to 1 microg/ml, respectively. DX-619 was also active against imipenem-resistant Bacteroides spp., with MIC(50)s/MIC(90)s of 0.25/1 microg/ml, respectively.
摘要
对新型去氟（6）喹诺酮类药物DX - 619针对厌氧菌的体外活性进行了评估。DX - 619对拟杆菌属、普雷沃菌属、梭杆菌属、微小单胞菌属、放线菌属和梭菌属表现出强效活性，其MIC50/MIC90分别≤0.03至0.25/≤0.03至1微克/毫升。DX - 619对耐亚胺培南的拟杆菌属也有活性，其MIC50/MIC90分别为0.25/1微克/毫升。
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