Lipman Terri H, Jawad Abbas F, Murphy Kathryn M, Tuttle Alan, Thompson Rebecca L, Ratcliffe Sarah J, Levitt Katz Lorraine E
CRNP, University of Pennsylvania School of Nursing, 420 Guardian Dr., Philadelphia, PA 19104, USA.
Diabetes Care. 2006 Nov;29(11):2391-5. doi: 10.2337/dc06-0517.
To determine the epidemiology of type 1 diabetes in children in Philadelphia, Pennsylvania, from 1995 through 1999 and compare these data with previous cohorts.
This is a report of a retrospective population-based registry maintained since 1985. Hospital records meeting the following criteria were reviewed: newly diagnosed type 1 diabetes, age 0-14 years, residing in Philadelphia at the time of diagnosis, and diagnosed from 1 January 1995 to 31 December 1999. The secondary source of validation was the School District of Philadelphia. Incidence rates by race and age were compared with 1985-1989 and 1990-1994 cohorts.
A total of 234 case subjects were identified, and the registry was determined to be 96% complete. The overall age-adjusted incidence rate in Philadelphia was 14.8 per 100,000/year. Incidence rates in Hispanic children (15.5 per 100,000/year) and white children (12.8 per 100,000/year) have been relatively stable over 15 years. The incidence in black children (15.2 per 100,000/year), however, has increased dramatically, rising 64% in children 5-9 years of age (14.9 per 100,000/year) and 37% in the 10- to 14-year age-group (26.9 per 100,000/year).
The overall incidence of type 1 diabetes in Philadelphia is increasing and is similar to other U.S. registries. These are the first data reporting a higher incidence in black children in a registry of children 0-14 years of age. The etiology of the marked increase in incidence in the black population is unknown and underscores the need to establish type 1 diabetes as a reportable disease, so that environmental risk factors may be thoroughly investigated.
确定1995年至1999年宾夕法尼亚州费城儿童1型糖尿病的流行病学情况，并将这些数据与之前的队列进行比较。
这是一份自1985年起维持的基于人群的回顾性登记报告。对符合以下标准的医院记录进行了审查：新诊断的1型糖尿病，年龄0至14岁，诊断时居住在费城，且诊断时间为1995年1月1日至1999年12月31日。验证的二级来源是费城学区。将种族和年龄别发病率与1985 - 1989年和1990 - 1994年队列进行了比较。
共识别出234例病例，登记的完整性确定为96%。费城总体年龄调整发病率为每年每10万人14.8例。西班牙裔儿童（每年每10万人15.5例）和白人儿童（每年每10万人12.8例）的发病率在15年里相对稳定。然而，黑人儿童的发病率（每年每10万人15.2例）急剧上升，5至9岁儿童上升了64%（每年每10万人14.9例），10至14岁年龄组上升了37%（每年每10万人26.9例）。
费城1型糖尿病的总体发病率正在上升，与美国其他登记处相似。这些是0至14岁儿童登记处首次报告黑人儿童发病率较高的数据。黑人人群发病率显著上升的病因尚不清楚，这突出了将1型糖尿病列为应报告疾病的必要性，以便对环境风险因素进行彻底调查。
