Heiman Gary A, Ottman Ruth, Saunders-Pullman Rachel J, Ozelius Laurie J, Risch Neil J, Bressman Susan B
Department of Epidemiology of Joseph L. Mailman School of Public Health, Columbia University, New York, New York 10032, USA.
Am J Med Genet B Neuropsychiatr Genet. 2007 Apr 5;144B(3):361-4. doi: 10.1002/ajmg.b.30431.
Prior studies suggest that obsessive-compulsive symptoms (OCS) and disorder (OCD) are co-morbid with dystonia. We tested if OCS/OCD is a clinical manifestation of the DYT1 dystonia mutation by interviewing members of families with an identified DYT1 mutation, and classifying by manifesting carriers (MC), non-manifesting carriers (NMC), and non-carriers (NC). We found that OCD/OCS are not increased in DYT1 mutation carriers compared with NC, nor is OCD associated with manifesting DYT1 dystonia.
先前的研究表明，强迫症状（OCS）和强迫症（OCD）与肌张力障碍共病。我们通过采访已确定存在DYT1突变的家族成员，并按照有症状携带者（MC）、无症状携带者（NMC）和非携带者（NC）进行分类，来测试OCS/OCD是否为DYT1肌张力障碍突变的一种临床表现。我们发现，与非携带者相比，DYT1突变携带者的强迫症/强迫症状并未增加，强迫症也与有症状的DYT1肌张力障碍无关。
