Cavallaro Roberto, Galardi Giuseppe, Cavallini Maria Cristina, Henin Marta, Amodio Stefano, Bellodi Laura, Comi Giancarlo
Department of Neuropsychiatric Sciences, Scientific Institute S. Raffaele Hospital, Vita-Salute-San Raffaele University Medical School.
Biol Psychiatry. 2002 Aug 15;52(4):356-61. doi: 10.1016/s0006-3223(02)01332-x.
A disturbed function of striato-thalamo-cortical circuitry is hypothesized to underlie idiopathic focal dystonia (IFD) and obsessive compulsive disorder (OCD), two severe and disabling neurologic and psychiatric disorders. Previous studies on small samples showed either higher obsessionality scores or higher frequency of OCD in dystonic patients than in normal control subjects. The aim of this study was to evaluate the frequency and familial loading of OCD in a population of patients with IFD.
We evaluated OCD diagnosis and family history in 76 patients affected by IFD.
Of our subjects 19.7% satisfied DSM-IV criteria for OCD diagnosis and had a family morbidity risk for OCD of 13.8%, significantly higher than that found in the general population.
Our results support the hypothesis of a common pathologic background for OCD and IFD, at least in a subgroup of IFD, indicating basal ganglia dysfunction.
纹状体 - 丘脑 - 皮质神经回路功能紊乱被认为是特发性局灶性肌张力障碍（IFD）和强迫症（OCD）这两种严重致残性神经和精神疾病的潜在病因。先前对小样本的研究表明，肌张力障碍患者的强迫观念得分高于正常对照受试者，或患强迫症的频率更高。本研究的目的是评估IFD患者群体中强迫症的发生率和家族聚集性。
我们评估了76例IFD患者的强迫症诊断和家族史。
我们的受试者中19.7%符合DSM - IV强迫症诊断标准，且患强迫症的家族发病风险为13.8%，显著高于普通人群。
我们的结果支持强迫症和IFD存在共同病理背景的假说，至少在IFD的一个亚组中如此，提示基底神经节功能障碍。
