Department of Neurology, University of Colorado, Denver, Colorado, USA.
Mov Disord. 2011 Jun;26(7):1206-17. doi: 10.1002/mds.23709. Epub 2011 Apr 11.
Nonmotor symptoms are increasingly recognized as important determinants of quality of life and disability in a wide range of movement disorders. There is a limited body of research suggesting that many of these symptoms are also commonly associated with primary and other genetic forms of dystonia. However, the significance, etiology, pathophysiology, and treatment of these symptoms remain poorly described. The following is a review of the literature that focuses primarily on the association of these types of dystonia with psychiatric disorders, cognition, sleep, pain, and autonomic symptoms. We will also discuss potential mechanisms and approaches to treatment for nonmotor features of dystonia.
非运动症状越来越被认为是广泛运动障碍中生活质量和残疾的重要决定因素。有有限的研究表明，许多这些症状也与原发性和其他遗传性肌张力障碍有关。然而，这些症状的意义、病因、病理生理学和治疗仍描述得很差。以下是对文献的综述，主要集中在这些类型的肌张力障碍与精神障碍、认知、睡眠、疼痛和自主症状的关联上。我们还将讨论肌张力障碍的非运动特征的潜在机制和治疗方法。
