Zhang Shujun, Zhao Ming, Bai Liming, Hasegawa Toshiaki, Wang Jinlan, Wang Liyan, Xue Hongyan, Deng Qigang, Xing Fenglan, Bai Yuhua, Sakai Jun-ichi, Bai Jiao, Koyanagi Rei, Tsukumo Yoshinori, Kataoka Takao, Nagai Kazuo, Hirose Katutoshi, Ando Masayoshi
Graduate School of Science and Technology and Department of Chemistry and Chemical Engineering, Niigata University, Ikarashi, 2-8050, Niigata, 950-2181, Japan.
J Nat Prod. 2006 Oct;69(10):1425-8. doi: 10.1021/np068015j.
Two new guaianolides, named chinensiolides D (5) and E (6), were isolated from Ixeris chinensis Nakai, and their structures were determined to be 10alpha-hydroxy-3-oxoguaia-11(13)-eno-12,6alpha-lactone (5) and 10alpha-hydroxy-3beta-O-[2,6-di(p-hydroxyphenylacetyl)-beta-glucopylanosyl]guaia-4(15),11(13)-dieno-12,6alpha-lactone (6). The first isolation of (11S)-10alpha-hydroxy-3-oxoguaia-4-eno-12,6alpha-lactone (4) from natural sources and its characterization are also reported. Chinenciolide E (6) showed significant growth inhibitory activity toward VA-13 malignant lung tumor cells (IC50 = 0.72 microM).
从中华苦荬菜中分离出两种新的愈创木内酯，命名为中华苦荬菜内酯D（5）和E（6），它们的结构被确定为10α-羟基-3-氧代愈创木-11(13)-烯-12,6α-内酯（5）和10α-羟基-3β-O-[2,6-二（对羟基苯乙酰基）-β-吡喃葡萄糖基]愈创木-4(15),11(13)-二烯-12,6α-内酯（6）。还报道了首次从天然来源分离出(11S)-10α-羟基-3-氧代愈创木-4-烯-12,6α-内酯（4）并对其进行了表征。中华苦荬菜内酯E（6）对VA-13恶性肺肿瘤细胞显示出显著的生长抑制活性（IC50 = 0.72 microM）。
