全缘叶麻风树素A和B，来自全缘叶麻风树乳汁的环状七肽。

Integerrimides A and B, cyclic heptapeptides from the latex of Jatropha integerrima.

作者信息

Mongkolvisut Wantana, Sutthivaiyakit Somyote, Leutbecher Heiko, Mika Sabine, Klaiber Iris, Möller Wolfgang, Rösner Harald, Beifuss Uwe, Conrad Jürgen

机构信息

Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand.

出版信息

J Nat Prod. 2006 Oct;69(10):1435-41. doi: 10.1021/np0602012.

DOI:10.1021/np0602012

PMID:17067157

Abstract

Two new cyclic heptapeptides, integerrimides A and B, have been isolated from the latex of Jatropha integerrima. Their structures were elucidated by using extensive 1D and 2D NMR, MS, and chemical degradation. At 50 microM both peptides 1 and 2 significantly inhibited neurite outgrowth in neuronal cell culture. They also partially inhibited proliferation of human IPC-298 melanoma cells as well as migration of human Capan II pancreatic carcinoma cells, but were inactive in HSV-1, antifungal, and antimalarial assays.

摘要

从麻疯树的乳胶中分离出了两种新的环七肽，即全缘麻疯树酰胺A和B。通过广泛的一维和二维核磁共振、质谱以及化学降解对它们的结构进行了阐明。在50微摩尔浓度下，肽1和肽2均显著抑制神经元细胞培养中的神经突生长。它们还部分抑制人IPC - 298黑色素瘤细胞的增殖以及人Capan II胰腺癌细胞的迁移，但在单纯疱疹病毒1型、抗真菌和抗疟疾试验中无活性。