环缩胍氨酸 D、Met-樱桃菌素环肽 B 及其类似物的平行合成及抗炎活性。
Parallel synthesis and anti-inflammatory activity of cyclic peptides cyclosquamosin D and Met-cherimolacyclopeptide B and their analogs.
机构信息
Faculté de Pharmacie, Laboratoire de Pharmacologie Marine, 5000 Monastir, Tunisia.
出版信息
Bioorg Med Chem Lett. 2010 Oct 1;20(19):5653-7. doi: 10.1016/j.bmcl.2010.08.033. Epub 2010 Aug 11.
Abstract
We report the parallel synthesis of two natural cyclopeptides, isolated from the seeds of Annona squamosa, cyclosquamosin D (A1), and Met-cherimolacyclopeptide B (B) and their analogs. All of the compounds were screened for anti-inflammatory activity by evaluating their inhibitory effects on the production of pro-inflammatory cytokines using the lipopolysaccharide stimulated macrophage J774A.1 cell line. Compounds having significant anti-inflammatory activity in suppressing the secretion of IL-6 and TNF-α have been identified, some of which exhibit activity superior to that observed with the natural products.
摘要
我们报告了两种天然环缩肽的平行合成，它们分别从 Annona squamosa 的种子中分离出来，分别是环 Squamosin D（A1）和 Met-cherimolacyclopeptide B（B）及其类似物。所有化合物都通过评估它们对脂多糖刺激的巨噬细胞 J774A.1 细胞系中促炎细胞因子产生的抑制作用来筛选抗炎活性。已经鉴定出具有抑制 IL-6 和 TNF-α分泌的显著抗炎活性的化合物，其中一些化合物的活性优于天然产物。
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