Lindshield Brian L, Canene-Adams Kirstie, Erdman John W
Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Arch Biochem Biophys. 2007 Feb 15;458(2):136-40. doi: 10.1016/j.abb.2006.09.012. Epub 2006 Oct 4.
In vitro lycopene is the most potent antioxidant among carotenoids. While antioxidant function may be relevant to health, we hypothesize that metabolites of lycopene may be bioactive and responsible for the beneficial effects of tomato product consumption. We term these metabolites "lycopenoids," which we believe may be produced from carotenoid monooxygenase (CMO) II, paralleling the production of retinoids from beta-carotene by CMO I. We present evidence suggesting that tomato carotenoid metabolites may be responsible for the reduced risk of prostate cancer seen in men consuming high levels of tomato products. Finally, we identify gaps in knowledge in this evolving area of carotenoid research.
体外实验表明，番茄红素是类胡萝卜素中最有效的抗氧化剂。虽然抗氧化功能可能与健康相关，但我们推测番茄红素的代谢产物可能具有生物活性，并对食用番茄制品的有益效果负责。我们将这些代谢产物称为“类番茄红素”，我们认为它们可能由类胡萝卜素单加氧酶（CMO）II产生，这与CMO I从β-胡萝卜素产生视黄醛的过程类似。我们提供的证据表明，食用大量番茄制品的男性前列腺癌风险降低可能与番茄类胡萝卜素代谢产物有关。最后，我们指出了这一不断发展的类胡萝卜素研究领域中存在的知识空白。
