Montenero A S, Bombardieri G, Barilaro C, Di Francesco P, Bertazzoni S, Santarelli P, Pisanó E, Alessandrini F, Possati G
Istituto di Cardiologia e Cardiochirurgia, Università Cattolica del S. Cuore, Rome, Italy.
Pacing Clin Electrophysiol. 1991 Feb;14(2 Pt 2):362-5. doi: 10.1111/j.1540-8159.1991.tb05122.x.
The aim of the study was to test the hypothesis that defibrillation with a single pulse shock can be obtained at lower energy using three epicardial patches configuration (one cathode and two anodes) instead of the conventional two patches. The total surface area of the two- and three-patches configuration was the same (10 cm2 vs 9.9 cm2). Epicardial spatial configuration was planned by using a computerized heart model. In ten anesthetized open-chest pigs, ventricular fibrillation was induced by using AC current through the mesh plaque epicardial custom-designed electrodes, and the minimum energy requirement for defibrillation was determined 15 seconds after the onset of stable ventricular fibrillation. Results were as follows (mean +/- standard deviation): Defibrillation Threshold 16 +/- 9 J 9 +/- 5 J P less than 0.01 CONCLUSIONS: three epicardial patches configuration significantly reduces energy requirements for defibrillation compared with two patches when single pulse shock is used.
与传统的两片式配置相比，使用三片式心外膜贴片配置（一个阴极和两个阳极）能以更低的能量实现单次脉冲电击除颤。两片式和三片式配置的总表面积相同（分别为10平方厘米和9.9平方厘米）。心外膜空间配置通过计算机心脏模型进行规划。在十只麻醉开胸猪中，通过定制设计的心外膜网状斑块电极施加交流电诱发室颤，并在稳定室颤发作15秒后确定除颤所需的最低能量。结果如下（平均值±标准差）：除颤阈值16±9焦耳，9±5焦耳，P＜0.01。结论：当使用单次脉冲电击时，与两片式贴片相比，三片式心外膜贴片配置显著降低了除颤所需的能量。
