测试PDQ - 39在多系统萎缩患者中的有效性。

Testing the validity of the PDQ-39 in patients with MSA.

作者信息

Schrag A, Jenkinson C, Selai C, Mathias C, Quinn N

机构信息

Department of Clinical Neurosciences, Royal Free and University College Medical School, University College London, London NW3 2PF, UK.

出版信息

Parkinsonism Relat Disord. 2007 Apr;13(3):152-6. doi: 10.1016/j.parkreldis.2006.08.008. Epub 2006 Oct 27.

DOI:10.1016/j.parkreldis.2006.08.008

PMID:17070089

Abstract

We assessed the validity of the PDQ-39, a disease-specific health-related quality of life instrument for patients with Parkinson's disease, in patients with multiple system atrophy (MSA). Two hundred and seventy-nine patients completed the PDQ-39, the EQ-5D, the Hospital Anxiety and Depression Scale, and scales of life satisfaction and disease severity. Ceiling and floor effects were noted in some dimensions, and Mobility was skewed towards the severe end of the spectrum. Apart from the dimension of Social Support, all dimensions had high internal consistency. The factor structure of the PDQ-39 in MSA was stable, and convergent and divergent validity with other measures of quality of life and mental health were good. However, many of the specific features of MSA are not reflected in the PDQ-39. Higher order factor analysis did not support the use of a single summary index. We conclude that the PDQ-39 has only limited validity in patients with MSA.

摘要

我们评估了帕金森病患者专用的疾病特异性健康相关生活质量工具PDQ - 39在多系统萎缩（MSA）患者中的有效性。279名患者完成了PDQ - 39、EQ - 5D、医院焦虑抑郁量表以及生活满意度和疾病严重程度量表。在某些维度上发现了天花板效应和地板效应，并且“活动能力”维度偏向严重一端。除“社会支持”维度外，所有维度都具有较高的内部一致性。PDQ - 39在MSA中的因子结构稳定，与其他生活质量和心理健康测量方法的收敛效度和区分效度良好。然而，MSA的许多具体特征在PDQ - 39中并未得到体现。高阶因子分析不支持使用单一的汇总指标。我们得出结论，PDQ - 39在MSA患者中的有效性有限。