Brown H M, Storey G
Br Med J. 1973 Jul 21;3(5872):161-4. doi: 10.1136/bmj.3.5872.161.
Thirty-one chronic perennial asthmatics aged from 2(1/2) to 16 years were treated with beclomethasone dipropionate pressurized aerosols for up to 20 months. Of these, 16 patients dependent on oral corticosteroid or corticotrophin for up to 11 years were successfully transferred to this treatment, with one exception. Steroid withdrawal symptoms were slight. Loss of weight, disappearance of Cushingoid features, and resumption of growth indicated lack of systemic side effects. Fifteen others inadequately controlled on bronchodilators or disodium cromoglycate, were also effectively treated, and no clinical evidence of adrenal suppression was noted.
31名年龄在2岁半至16岁之间的慢性持续性哮喘患者接受了丙酸倍氯米松压力定量气雾剂治疗,治疗时间长达20个月。其中,16名依赖口服皮质类固醇或促肾上腺皮质激素长达11年的患者成功转为这种治疗方法,仅有1例例外。撤药症状轻微。体重减轻、库欣样体征消失以及生长恢复表明无全身副作用。另外15名使用支气管扩张剂或色甘酸钠控制不佳的患者也得到了有效治疗,且未观察到肾上腺抑制的临床证据。