Kok Esther T, Bohnen Arthur M, Jonkheijm Rikkert, Gouweloos Jochem, Groeneveld Frans P M J, Thomas Siep, Bosch J L H Ruud
Department of General Practice, Erasmus Medical Centre, Rotterdam, The Netherlands.
Urology. 2006 Oct;68(4):784-9. doi: 10.1016/j.urology.2006.04.008.
To determine which case-definition of clinical benign prostatic hyperplasia (BPH) has the best predictive value for general practitioner visits for lower urinary tract symptoms (LUTS) suggestive of BPH. The incidence and prevalence rates of general practitioner visits for LUTS were also determined.
A longitudinal, population-based study from 1995 to 2003 was conducted among 1688 men aged 50 to 78 years old. Data were collected on physical urologic parameters, quality of life, and symptom severity as determined from the International Prostate Symptom Score. Information on health-care-seeking behavior of all participants was collected from the general practitioner (GP) record using a computerized search engine and an additional manual check of the electronically selected files.
The incidence and prevalence rate of the men at risk was 19.6% and 14.0%, respectively, and these rates increased with age. For sensitivity and the positive predictive value, the case-definition of clinical BPH as an International Prostate Symptom Score greater than 7 had the best predictive value for GP visits for LUTS within 2 years after baseline.
Because only marginal improvement (greater specificity but lower sensitivity) in the prediction of GP visits for LUTS was possible by adding information on prostate volume and flow, for the prediction of future GP visits for LUTS suggestive of BPH, we suggest that the International Prostate Symptom Score questionnaire be used and that estimation of the prostate volume and flow is not required.
确定哪种临床良性前列腺增生(BPH)病例定义对因提示BPH的下尿路症状(LUTS)而就诊全科医生具有最佳预测价值。还确定了因LUTS就诊全科医生的发病率和患病率。
1995年至2003年对1688名年龄在50至78岁的男性进行了一项基于人群的纵向研究。收集了有关物理泌尿学参数、生活质量以及根据国际前列腺症状评分确定的症状严重程度的数据。使用计算机搜索引擎并对电子筛选文件进行额外人工检查从全科医生(GP)记录中收集所有参与者的就医行为信息。
有风险男性的发病率和患病率分别为19.6%和14.0%,且这些比率随年龄增加。就敏感性和阳性预测值而言,将临床BPH病例定义为国际前列腺症状评分大于7对基线后2年内因LUTS就诊全科医生具有最佳预测价值。
由于通过添加前列腺体积和流量信息对因LUTS就诊全科医生的预测仅能有边际改善(更高的特异性但更低的敏感性),对于预测未来因提示BPH的LUTS就诊全科医生,我们建议使用国际前列腺症状评分问卷,且无需估计前列腺体积和流量。