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1
CD8+ cell anti-HIV activity correlates with the clinical state of the infected individual.CD8 + 细胞的抗HIV活性与受感染个体的临床状态相关。
J Clin Invest. 1991 Apr;87(4):1462-6. doi: 10.1172/JCI115153.
2
Suppression of HIV replication by lymphoid tissue CD8+ cells correlates with the clinical state of HIV-infected individuals.淋巴组织CD8 +细胞对HIV复制的抑制作用与HIV感染者的临床状态相关。
Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13125-30. doi: 10.1073/pnas.93.23.13125.
3
Tissue infiltration in a CD8 lymphocytosis syndrome associated with human immunodeficiency virus-1 infection has the phenotypic appearance of an antigenically driven response.与人类免疫缺陷病毒1型感染相关的CD8淋巴细胞增多综合征中的组织浸润具有抗原驱动反应的表型特征。
J Clin Invest. 1993 May;91(5):2216-25. doi: 10.1172/JCI116448.
4
Infection of CD8+ T lymphocytes with HIV. Requirement for interaction with infected CD4+ cells and induction of infectious virus from chronically infected CD8+ cells.HIV对CD8+ T淋巴细胞的感染。与受感染的CD4+细胞相互作用的必要性以及从慢性感染的CD8+细胞中诱导产生传染性病毒。
J Immunol. 1991 Apr 1;146(7):2220-6.
5
Quantitative changes in T helper inducer (CD4+ CD45RA-), T suppressor inducer (CD4+ CD45RA+), T suppressor (CD8+ CD11b+), and T cytotoxic (CD8+ CD11b-) subsets in human immunodeficiency virus infection.人类免疫缺陷病毒感染中辅助性T诱导细胞（CD4+ CD45RA-）、抑制性T诱导细胞（CD4+ CD45RA+）、抑制性T细胞（CD8+ CD11b+）和细胞毒性T细胞（CD8+ CD11b-）亚群的定量变化
J Clin Lab Anal. 1991;5(2):96-100. doi: 10.1002/jcla.1860050205.
6
CD8+ T cells from HIV-1-infected individuals inhibit acute infection by human and primate immunodeficiency viruses.来自HIV-1感染者的CD8 + T细胞可抑制人类和灵长类免疫缺陷病毒的急性感染。
Cell Immunol. 1991 Oct 15;137(2):420-8. doi: 10.1016/0008-8749(91)90090-x.
7
CD8+ lymphocytes suppress HIV production by autologous CD4+ cells without eliminating the infected cells from culture.CD8 + 淋巴细胞通过自体CD4 + 细胞抑制HIV产生，而不将感染细胞从培养物中清除。
Cell Immunol. 1990 Jul;128(2):628-34. doi: 10.1016/0008-8749(90)90054-u.
8
Different meaning of CD38 molecule expression on CD4+ and CD8+ cells of children perinatally infected with human immunodeficiency virus type 1 infection surviving longer than five years.1型人类免疫缺陷病毒围产期感染且存活超过五年的儿童CD4+和CD8+细胞上CD38分子表达的不同意义
Pediatr Res. 1998 Jun;43(6):752-8. doi: 10.1203/00006450-199806000-00007.
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Interference with human immunodeficiency virus (HIV) replication by CD8+ T cells in peripheral blood leukocytes of asymptomatic HIV carriers in vitro.体外研究无症状HIV携带者外周血白细胞中CD8 + T细胞对人类免疫缺陷病毒（HIV）复制的干扰作用。
J Virol. 1990 Jul;64(7):3399-406. doi: 10.1128/JVI.64.7.3399-3406.1990.
10
CD8+CD38+ and CD8+DR+ peripheral blood lymphoid subsets of HIV-infected intravenous drug abusers correlate with CD4+ cell counts and proliferation to mitogens.HIV感染的静脉注射吸毒者的CD8+CD38+和CD8+DR+外周血淋巴细胞亚群与CD4+细胞计数及对丝裂原的增殖反应相关。
Cell Immunol. 1993 Aug;150(1):72-80. doi: 10.1006/cimm.1993.1179.

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Non-cytotoxic functions of CD8 T cells: "repentance of a serial killer".CD8 T 细胞的非细胞毒性功能：“连环杀手的忏悔”。
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Canonical Wnts Mediate CD8 T Cell Noncytolytic Anti-HIV-1 Activity and Correlate with HIV-1 Clinical Status.经典 Wnt 信号通路介导 CD8 T 细胞非细胞溶解抗 HIV-1 活性，并与 HIV-1 临床状态相关。
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Noncytolytic CD8+ Cell Mediated Antiviral Response Represents a Strong Element in the Immune Response of Simian Immunodeficiency Virus-Infected Long-Term Non-Progressing Rhesus Macaques.非细胞溶解性CD8 +细胞介导的抗病毒反应是猿猴免疫缺陷病毒感染的长期不进展恒河猴免疫反应中的一个重要因素。
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The CD8+ cell non-cytotoxic antiviral response affects RNA polymerase II-mediated human immunodeficiency virus transcription in infected CD4+ cells.CD8 + 细胞的非细胞毒性抗病毒反应影响感染的CD4 + 细胞中RNA聚合酶II介导的人类免疫缺陷病毒转录。
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Discovery of another anti-HIV protein in the search for the CD8+ cell anti-HIV Factor.在寻找CD8 +细胞抗HIV因子的过程中发现了另一种抗HIV蛋白。
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The CD8 antiviral factor (CAF) can suppress HIV-1 transcription from the long terminal repeat (LTR) promoter in the absence of elements upstream of the CATATAA box.CD8抗病毒因子（CAF）在缺乏CATATAA框上游元件的情况下，可抑制HIV-1从长末端重复序列（LTR）启动子的转录。
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本文引用的文献

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Cytotoxic T-cell immunity to influenza.针对流感的细胞毒性T细胞免疫
N Engl J Med. 1983 Jul 7;309(1):13-7. doi: 10.1056/NEJM198307073090103.
2
Cytotoxic t cells in cytomegalovirus infection: HLA-restricted T-lymphocyte and non-T-lymphocyte cytotoxic responses correlate with recovery from cytomegalovirus infection in bone-marrow-transplant recipients.巨细胞病毒感染中的细胞毒性T细胞：骨髓移植受者中HLA限制性T淋巴细胞和非T淋巴细胞的细胞毒性反应与巨细胞病毒感染的恢复相关。
N Engl J Med. 1982 Jul 1;307(1):7-13. doi: 10.1056/NEJM198207013070102.
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T cell-mediated immunity to oncornavirus-induced tumors. II. Ability of different T cell sets to prevent tumor growth in vivo.T细胞介导的对致癌RNA病毒诱导肿瘤的免疫反应。II. 不同T细胞群体在体内预防肿瘤生长的能力。
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Functional activity in vivo of effector T cell populations. II. Anti-tumor activity exhibited by syngeneic anti-MoMULV-specific cytolytic T cell clones.效应T细胞群体在体内的功能活性。II. 同基因抗MoMULV特异性细胞溶解T细胞克隆所表现出的抗肿瘤活性。
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Evaluation of natural killer cell activity in patients with persistent generalized lymphadenopathy and acquired immunodeficiency syndrome.持续性全身性淋巴结病和获得性免疫缺陷综合征患者自然杀伤细胞活性的评估。
Clin Immunol Immunopathol. 1985 Aug;36(2):141-50. doi: 10.1016/0090-1229(85)90115-1.
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AIDS virus-specific cytotoxic T lymphocytes in lung disorders.肺部疾病中的艾滋病病毒特异性细胞毒性T淋巴细胞
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HIV-specific cytotoxic T lymphocytes in seropositive individuals.血清反应阳性个体中的HIV特异性细胞毒性T淋巴细胞。
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Mechanism of defective NK cell activity in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex. I. Defective trigger on NK cells for NKCF production by target cells, and partial restoration by IL 2.获得性免疫缺陷综合征（AIDS）及AIDS相关综合征患者自然杀伤（NK）细胞活性缺陷的机制。I. 靶细胞触发NK细胞产生NK细胞趋化因子（NKCF）存在缺陷，而白细胞介素2（IL 2）可使其部分恢复。
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Human immunodeficiency virus-related lymphocytic alveolitis.人类免疫缺陷病毒相关淋巴细胞性肺泡炎
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CD8 + 细胞的抗HIV活性与受感染个体的临床状态相关。

CD8+ cell anti-HIV activity correlates with the clinical state of the infected individual.

作者信息

Mackewicz C E, Ortega H W, Levy J A

机构信息

Department of Medicine, University of California School of Medicine, San Francisco 94143-0128.

出版信息

J Clin Invest. 1991 Apr;87(4):1462-6. doi: 10.1172/JCI115153.

DOI:10.1172/JCI115153
PMID:1707063
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC295198/
Abstract

The extent of antiviral activity exhibited in vitro by CD8+lymphocytes from individuals infected by HIV-1 correlates significantly with their clinical status. CD8+ lymphocytes from asymptomatic subjects were found to inhibit HIV-1 replication by 90% or greater at effector/target (E/T) ratios ranging from as low as 0.05 to 0.25. CD8+ cells from 17 of 19 (89%) of these subjects suppressed replication at an E/T ratio of 0.10 or less. CD8+ lymphocytes from symptomatic patients (non-AIDS) inhibited HIV-1 replication at E/T ratios ranging from 0.05 to 1.0, and CD8+ cells from 8 of 13 (62%) required ratios greater than 0.10. As a group, patients with AIDS exhibited the lowest degree of anti-HIV activity with their CD8+ lymphocytes. The effective range of E/T ratios from AIDS patients was 0.10-2.0, and 9 of 10 (90%) required E/T ratios greater than 0.25. This anti-HIV activity exhibited by CD8+ cells also correlated significantly with the subject's peripheral blood CD4+ cell count. The relative extent of CD8+ cell anti-HIV-1 activity was not found dependent on variations in the CD4+ target cells and viruses used. These findings suggest that the decreased CD8+ cell antiviral activity is related to progression to disease in HIV-infected individuals.

摘要

来自感染HIV-1个体的CD8+淋巴细胞在体外表现出的抗病毒活性程度与其临床状态显著相关。发现无症状受试者的CD8+淋巴细胞在效应细胞/靶细胞（E/T）比率低至0.05至0.25的范围内可抑制HIV-1复制达90%或更高。这些受试者中19人中有17人（89%）的CD8+细胞在E/T比率为0.10或更低时抑制了复制。有症状患者（非艾滋病患者）的CD8+淋巴细胞在E/T比率为0.05至1.0的范围内抑制HIV-1复制，13人中有8人（62%）的CD8+细胞需要大于0.10的比率。作为一个群体，艾滋病患者的CD8+淋巴细胞表现出最低程度的抗HIV活性。艾滋病患者的E/T比率有效范围为0.10 - 2.0，10人中有9人（90%）需要大于0.25的E/T比率。CD8+细胞表现出的这种抗HIV活性也与受试者外周血CD4+细胞计数显著相关。未发现CD8+细胞抗HIV-1活性的相对程度取决于所用CD4+靶细胞和病毒的差异。这些发现表明，CD8+细胞抗病毒活性的降低与HIV感染个体病情进展有关。