Littorin B, Blom P, Schölin A, Arnqvist H J, Blohmé G, Bolinder J, Ekbom-Schnell A, Eriksson J W, Gudbjörnsdottir S, Nyström L, Ostman J, Sundkvist G
Department of Clinical Sciences, University of Lund, Malmö University Hospital, Malmö, Sweden.
Diabetologia. 2006 Dec;49(12):2847-52. doi: 10.1007/s00125-006-0426-x. Epub 2006 Oct 27.
AIMS/HYPOTHESIS: Low plasma vitamin D concentrations may promote the development of type 1 diabetes. To test this hypothesis, we measured plasma 25-hydroxyvitamin D (25OHD) in young adults with type 1 diabetes.
The nationwide Diabetes Incidence Study in Sweden (DISS) covers 15- to 34-year-old people with newly diagnosed diabetes. Blood samples at diagnosis were collected during the 2-year period 1987/1988. Patients with islet antibodies (islet cell antibodies, GAD antibodies or tyrosine phosphatase-like protein antibodies) were defined as having autoimmune type 1 diabetes. Plasma 25OHD was measured in samples taken from 459 patients at the time of diagnosis, and in 138 of these subjects 8 years later. The results were compared with age- and sex-matched control subjects (n=208).
At diagnosis, plasma 25OHD levels were significantly lower in patients with type 1 diabetes than in control subjects (82.5+/-1.3 vs 96.7+/-2.0 nmol/l; p<0.0001). Eight years later, plasma 25OHD had decreased in patients (81.5+/-2.6 nmol/l; p=0.04). Plasma 25OHD levels were significantly lower in diabetic men than in diabetic women at diagnosis (77.9+/-1.4 vs 90.1+/-2.4 nmol/l; p<0.0001) and at follow-up (77.1+/-2.8 nmol/l vs 87.2+/-4.5 nmol/l; p=0.048).
CONCLUSIONS/INTERPRETATION: The plasma 25OHD level was lower at diagnosis of autoimmune type 1 diabetes than in control subjects, and may have a role in the development of type 1 diabetes. Plasma 25OHD levels were lower in men than in women with type 1 diabetes. This difference may be relevant to the high incidence of type 1 diabetes among young adult men.
目的/假设：血浆维生素D浓度低可能会促进1型糖尿病的发展。为验证这一假设，我们测量了1型糖尿病青年成人的血浆25-羟基维生素D（25OHD）水平。
瑞典全国糖尿病发病率研究（DISS）涵盖15至34岁新诊断糖尿病患者。诊断时的血样采集于1987/1988这两年期间。有胰岛抗体（胰岛细胞抗体、谷氨酸脱羧酶抗体或酪氨酸磷酸酶样蛋白抗体）的患者被定义为患有自身免疫性1型糖尿病。在459例患者诊断时采集的样本中测量血浆25OHD水平，并在其中138例受试者8年后再次测量。结果与年龄和性别匹配的对照受试者（n = 208）进行比较。
诊断时，1型糖尿病患者的血浆25OHD水平显著低于对照受试者（82.5±1.3对96.7±2.0 nmol/l；p<0.0001）。8年后，患者的血浆25OHD水平下降（81.5±2.6 nmol/l；p = 0.04）。诊断时，糖尿病男性的血浆25OHD水平显著低于糖尿病女性（77.9±1.4对90.1±2.4 nmol/l；p<0.0001），随访时也是如此（77.1±2.8 nmol/l对87.2±4.5 nmol/l；p = 0.048）。
结论/解读：自身免疫性1型糖尿病诊断时的血浆25OHD水平低于对照受试者，可能在1型糖尿病的发展中起作用。1型糖尿病男性的血浆25OHD水平低于女性。这种差异可能与青年成年男性中1型糖尿病的高发病率有关。
