Shi Liang-Hui, Zhu Xiao-Qun, Zhao Guo-Hai, Xia Ya-Bin, Zhang Yi-Sheng
Department of Surgery, Affiliated Yijishan Hospital, Wannan Medical College, Wuhu 241001, Anhui Province, China.
World J Gastroenterol. 2006 Oct 21;12(39):6285-9. doi: 10.3748/wjg.v12.i39.6285.
To investigate the expression of insulin-like growth factor binding protein-2 (IGFBP-2) in gastric carcinoma and its clinical significance and to explore its relationship with cell proliferation.
Expressions of IGFBP-2 and Ki-67 in 118 cases of gastric carcinoma and 40 cases of normal gastric mucosa were detected by EnVision immunohistochemical technique.
Expression of IGFBP-2 in gastric carcinoma was higher than that in normal gastric mucosa (P < 0.01). There was no difference between high- and low-grade gastric carcinoma (P > 0.05). Expression of IGFBP-2 in advanced gastric carcinoma was higher than that in early gastric carcinoma (P < 0.05). Expression of IGFBP-2 in gastric carcinoma with lymph node metastasis was higher than that without lymph node metastasis (P < 0.01). IGFBP-2 expression was a positively related to the clinical stage of gastric carcinoma (P < 0.01). There was a positive correlation between IGFBP-2 and Ki-67 (P < 0.05).
IGFBP-2 may be involved in carcino-genesis and progression of gastric carcinoma by promoting cell proliferation.
探讨胰岛素样生长因子结合蛋白2（IGFBP-2）在胃癌中的表达及其临床意义，并探讨其与细胞增殖的关系。
采用EnVision免疫组化技术检测118例胃癌组织及40例正常胃黏膜组织中IGFBP-2和Ki-67的表达。
胃癌组织中IGFBP-2的表达高于正常胃黏膜组织（P<0.01）。高、低分化胃癌之间差异无统计学意义（P>0.05）。进展期胃癌组织中IGFBP-2的表达高于早期胃癌（P<0.05）。有淋巴结转移的胃癌组织中IGFBP-2的表达高于无淋巴结转移者（P<0.01）。IGFBP-2表达与胃癌临床分期呈正相关（P<0.01）。IGFBP-2与Ki-67呈正相关（P<0.05）。
IGFBP-2可能通过促进细胞增殖参与胃癌的发生发展。
