环氧化酶-2表达及其与大肠腺瘤增殖的关系。

Cyclooxygenase-2 expression and its relationship with proliferation of colorectal adenomas.

作者信息

Sato Takanobu, Yoshinaga Keigo, Okabe Satoshi, Okawa Takuya, Higuchi Tetsuro, Enomoto Masayuki, Takizawa Touichirou, Sugihara Kenichi

机构信息

Digestive Surgery, Tokyo Medical and Dental University Graduate School, Tokyo, Japan.

出版信息

Jpn J Clin Oncol. 2003 Dec;33(12):631-5. doi: 10.1093/jjco/hyg114.

DOI:10.1093/jjco/hyg114

PMID:14769841

Abstract

BACKGROUND

Cyclooxygenase (COX)-2 may be linked to carcinogenesis. In the previous study, we examined COX-2 expression immunohistochemically in 95 adenomas and reported a significant correlation between its expression and the grade of dysplasia. To clarify the correlation between COX-2 expression and cell proliferation, we investigated Ki-67 labeling index using immunohistochemistry and its correlation with COX-2 expression.

METHODS

Immunohistological staining for Ki-67 antigen was performed on 95 colorectal adenomas previously reported.

RESULTS

The Ki-67 labeling index was significantly higher in the high-COX-2 group than in the low-COX-2 and negative groups in adenomas with moderate (44.5 +/- 6.4% vs 33.0 +/- 2.6%, 39.0 +/- 6.2%; P = 0.01, P < 0.001, respectively) or severe dysplasia (47.2 +/- 7.6% vs 40.3 +/- 7.2%, 35.0 +/- 5.4%; P = 0.02, P = 0.005, respectively). There was no correlation between Ki-67 labeling index and COX-2 expression in mild dysplasia.

CONCLUSIONS

These results suggest that COX-2 may play a causal role in cell proliferation in carcinogenesis.

摘要

背景

环氧化酶（COX）-2可能与致癌作用相关。在先前的研究中，我们通过免疫组织化学检测了95例腺瘤中COX-2的表达，并报告其表达与发育异常程度之间存在显著相关性。为了阐明COX-2表达与细胞增殖之间的相关性，我们使用免疫组织化学研究了Ki-67标记指数及其与COX-2表达的相关性。

方法

对先前报道的95例大肠腺瘤进行Ki-67抗原的免疫组织化学染色。

结果

在中度（分别为44.5±6.4%对33.0±2.6%，39.0±6.2%；P = 0.01，P < 0.001）或重度发育异常（分别为47.2±7.6%对40.3±7.2%，35.0±5.4%；P = 0.02，P = 0.005）的腺瘤中，高COX-2组的Ki-67标记指数显著高于低COX-2组和阴性组。在轻度发育异常中，Ki-67标记指数与COX-2表达之间无相关性。