Sato Takanobu, Yoshinaga Keigo, Okabe Satoshi, Okawa Takuya, Higuchi Tetsuro, Enomoto Masayuki, Takizawa Touichirou, Sugihara Kenichi
Digestive Surgery, Tokyo Medical and Dental University Graduate School, Tokyo, Japan.
Jpn J Clin Oncol. 2003 Dec;33(12):631-5. doi: 10.1093/jjco/hyg114.
Cyclooxygenase (COX)-2 may be linked to carcinogenesis. In the previous study, we examined COX-2 expression immunohistochemically in 95 adenomas and reported a significant correlation between its expression and the grade of dysplasia. To clarify the correlation between COX-2 expression and cell proliferation, we investigated Ki-67 labeling index using immunohistochemistry and its correlation with COX-2 expression.
Immunohistological staining for Ki-67 antigen was performed on 95 colorectal adenomas previously reported.
The Ki-67 labeling index was significantly higher in the high-COX-2 group than in the low-COX-2 and negative groups in adenomas with moderate (44.5 +/- 6.4% vs 33.0 +/- 2.6%, 39.0 +/- 6.2%; P = 0.01, P < 0.001, respectively) or severe dysplasia (47.2 +/- 7.6% vs 40.3 +/- 7.2%, 35.0 +/- 5.4%; P = 0.02, P = 0.005, respectively). There was no correlation between Ki-67 labeling index and COX-2 expression in mild dysplasia.
These results suggest that COX-2 may play a causal role in cell proliferation in carcinogenesis.
环氧化酶（COX）-2可能与致癌作用相关。在先前的研究中，我们通过免疫组织化学检测了95例腺瘤中COX-2的表达，并报告其表达与发育异常程度之间存在显著相关性。为了阐明COX-2表达与细胞增殖之间的相关性，我们使用免疫组织化学研究了Ki-67标记指数及其与COX-2表达的相关性。
对先前报道的95例大肠腺瘤进行Ki-67抗原的免疫组织化学染色。
在中度（分别为44.5±6.4%对33.0±2.6%，39.0±6.2%；P = 0.01，P < 0.001）或重度发育异常（分别为47.2±7.6%对40.3±7.2%，35.0±5.4%；P = 0.02，P = 0.005）的腺瘤中，高COX-2组的Ki-67标记指数显著高于低COX-2组和阴性组。在轻度发育异常中，Ki-67标记指数与COX-2表达之间无相关性。
这些结果表明COX-2可能在致癌过程中的细胞增殖中起因果作用。
