Stiller D, Katenkamp D
Virchows Arch A Pathol Anat Histol. 1975 Jun 23;367(1):73-81. doi: 10.1007/BF00430774.
This study presents the results of light-microscopic, histochemical, and electron-microscopic investigations of dense (inclusion) bodies in a recurring digital fibrous tumor of childhood. At ultrastructural level it was possible to observe several stages of development correlated with changes of ergastoplasmic reticulum. The viral nature of these bodies was refuted and the conclusion was drawn that their formation is associated with a disturbed intracellular metabolism. The defective intracellular transport of collagen precursors followed by abnormal deposition of collagenous proteins, which are also to some extent abnormally aggregated, could be of special importance.
本研究展示了对儿童复发性指部纤维瘤中致密（包涵体）小体进行光学显微镜、组织化学及电子显微镜研究的结果。在超微结构水平上，能够观察到与内质网变化相关的几个发育阶段。这些小体的病毒性质被否定，得出的结论是它们的形成与细胞内代谢紊乱有关。胶原蛋白前体的细胞内运输缺陷，随后是胶原蛋白的异常沉积，且这些胶原蛋白在一定程度上也存在异常聚集，这可能具有特别重要的意义。
