气候变化对特应性皮炎患儿的影响。

Effect of climatic change in children with atopic eczema.

作者信息

Byremo G, Rød G, Carlsen K H

机构信息

Voksentoppen, Department of Paediatrics, Rikshospitalet-Radiumhospitalet, University of Oslo, Oslo, Norway.

出版信息

Allergy. 2006 Dec;61(12):1403-10. doi: 10.1111/j.1398-9995.2006.01209.x.

DOI:10.1111/j.1398-9995.2006.01209.x

PMID:17073869

Abstract

BACKGROUND

Climate and sunlight (ultraviolet radiation) influence activity of atopic eczema.

OBJECTIVE

To evaluate the effect of moving from a subarctic/temperate climate to a sunny subtropical climate on children's atopic eczema.

METHODS

Children, 4-13 years, with severe atopic eczema were randomized to stay 4 weeks in Gran Canary (index patients = 30) and home in Norway (controls = 26), with a follow up of 3 months. SCORing of Atopic Dermatitis (SCORAD) was primary variable, and secondary were Children's Dermatology Life Quality Index (CDLQI), Staphylococcus aureus skin colonization and pharmacological skin treatment.

RESULTS

SCORing of Atopic Dermatitis decreased from 37.2 (29.4-44.9) to 12.2 (9.0-15.4) [mean (95% confidence intervals)] after 4 weeks and 21.2 (17.2-25.1) 3 months thereafter in index patients (P < 0.0005), much less in controls.Children's Dermatology Life Quality Index in the index group improved from 8.7 to 2.2 and 4.5 after 4 weeks and 3 months (P < 0.0005), not in controls. Bacterial skin colonization with S. aureus decreased in the index group from 23/30 (77%) to 12/30 (40%; P = 0.001) and 12/30 (40%; P = 0.005) after 1 month and 3 months, and the use of local steroids decreased in index patients but not in controls.

CONCLUSIONS

The change from a subartic/temperate to a subtropical climate for 4 weeks improved significantly skin symptoms (SCORAD) and quality of life, even for 3 months after return.

摘要

背景

气候和阳光（紫外线辐射）会影响特应性皮炎的活动。

目的

评估从亚北极/温带气候转移到阳光充足的亚热带气候对儿童特应性皮炎的影响。

方法

将4至13岁患有严重特应性皮炎的儿童随机分为两组，一组在大加那利岛停留4周（指数患者=30），另一组留在挪威家中（对照组=26），随访3个月。特应性皮炎评分（SCORAD）为主要变量，次要变量为儿童皮肤病生活质量指数（CDLQI）、金黄色葡萄球菌皮肤定植情况和皮肤药物治疗情况。

结果

指数患者在4周后，特应性皮炎评分从37.2（29.4 - 44.9）降至12.2（9.0 - 15.4）[均值（95%置信区间）]，3个月后降至21.2（17.2 - 25.1）（P < 0.0005），对照组下降幅度小得多。指数组儿童皮肤病生活质量指数在4周和3个月后分别从8.7改善至2.2和4.5（P < 0.0005），对照组无改善。指数组金黄色葡萄球菌皮肤定植在1个月和3个月后分别从23/30（77%）降至12/30（40%；P = 0.001）和12/30（40%；P = 0.005），指数患者局部类固醇的使用减少，而对照组未减少。