Schneider Lisa F, Warren Michelle P
Department of Obstetrics and Gynecology and Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.
Fertil Steril. 2006 Dec;86(6):1744-9. doi: 10.1016/j.fertnstert.2006.05.051. Epub 2006 Oct 30.
To determine whether ghrelin, an orexigen released by the stomach, is elevated in women with hypothalamic amenorrhea who are of normal weight and whether this is associated with abnormal eating behaviors.
Controlled clinical study.
Healthy volunteers in an academic research environment.
PATIENT(S): Twenty-seven women with functional hypothalamic amenorrhea (FHA) and 42 normally menstruating women.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Ghrelin and eating behavior.
RESULT(S): Ghrelin was significantly elevated in FHA (648.4 +/- 92.0 pg/mL vs. controls 596.7 +/- 79.0 pg/mL), while leptin, although lower, was not significantly so (FHA 5.4 +/- 2.8 ng/mL vs. controls 6.4 +/- 3 ng/mL). Eating Attitudes Test (EAT) scores were also significantly elevated in FHA (15.3 +/- 10.6 vs. controls 10.3 +/- 8.4), particularly on the subscale that measured bulimic behaviors. However, FHA patients consumed significantly more kilocalories (1,930 kcal/day vs. 1,588 kcal/day).
CONCLUSION(S): High ghrelin in women with FHA may be linked to abnormal dietary behaviors, as reflected in high EAT scores yet characterized by normal caloric intake. Ghrelin may act as a restraining metabolic signal preventing a return to cyclicity in women with both disordered eating and FHA, prolonging amenorrhea when leptin has returned to normal.
确定胃分泌的促食欲素——胃饥饿素在体重正常的下丘脑性闭经女性中是否升高，以及这是否与异常饮食行为有关。
对照临床研究。
学术研究环境中的健康志愿者。
27名功能性下丘脑性闭经（FHA）女性和42名月经正常的女性。
无。
胃饥饿素和饮食行为。
FHA患者的胃饥饿素显著升高（648.4±92.0 pg/mL，对照组为596.7±79.0 pg/mL），而瘦素虽然较低，但差异不显著（FHA为5.4±2.8 ng/mL，对照组为6.4±3 ng/mL）。FHA患者的饮食态度测试（EAT）得分也显著升高（15.3±10.6，对照组为10.3±8.4），尤其是在测量暴食行为的子量表上。然而，FHA患者摄入的千卡热量显著更多（1930千卡/天，对照组为1588千卡/天）。
FHA女性中胃饥饿素水平升高可能与异常饮食行为有关，如EAT得分高所示，但热量摄入正常。胃饥饿素可能作为一种抑制性代谢信号，阻止饮食失调和FHA女性恢复月经周期，在瘦素恢复正常时延长闭经时间。
