Scheid Jennifer L, Williams Nancy I, West Sarah L, VanHeest Jaci L, De Souza Mary Jane
Women's Exercise and Bone Health Laboratory, Graduate Department of Exercise Science, University of Toronto, Toronto, Ontario, Canada M5S 2W6.
Appetite. 2009 Feb;52(1):184-92. doi: 10.1016/j.appet.2008.09.016. Epub 2008 Sep 25.
The purpose of this study was twofold: (1) to determine if gastrointestinal hormones, associated with energy intake and energy balance, are altered in exercising women with hypothalamic amenorrhea and (2) to assess the association between gastrointestinal hormones and behavioural indicators of subclinical disordered eating in exercising women with hypothalamic amenorrhea. This cross-sectional study analyzed serum ghrelin, peptide YY (PYY), glucagon-like peptide-1 (GLP-1), menstrual status (by E1G and PdG), resting energy expenditure (REE), and subclinical eating behaviours in sedentary ovulatory (SedOv), exercising ovulatory (ExOv), and exercising amenorrheic (ExAmen) women. Groups were similar with respect to age (23.8+/-0.6 years) and BMI (21.4+/-0.3 kg/m(2)). The ratio of REE to predicted REE (REE:predicted REE) was 0.94+/-0.02, 0.94+/-0.02, and 0.88+/-0.02 in the SedOv, ExOv, and ExAmen groups, respectively. The REE:predicted REE in the ExAmen group was consistent with an energy deficiency. LogPYY, ghrelin, dietary cognitive restraint, and drive for thinness were elevated in the ExAmen group compared to other groups. GLP-1 concentrations were similar among groups. LogPYY correlated with drive for thinness and REE/FFM. In conclusion, fasting PYY and ghrelin concentrations are elevated in exercising women with FHA and both gastrointestinal peptides may serve as a proxy indicator of energy deficiency in this population.
（1）确定与能量摄入和能量平衡相关的胃肠激素在患有下丘脑性闭经的运动女性中是否发生改变；（2）评估胃肠激素与患有下丘脑性闭经的运动女性亚临床饮食失调行为指标之间的关联。这项横断面研究分析了久坐的排卵正常女性（SedOv）、运动的排卵正常女性（ExOv）和运动性闭经女性（ExAmen）的血清胃饥饿素、肽YY（PYY）、胰高血糖素样肽-1（GLP-1）、月经状况（通过E1G和PdG）、静息能量消耗（REE）以及亚临床饮食行为。各组在年龄（23.8±0.6岁）和BMI（21.4±0.3kg/m²）方面相似。SedOv组、ExOv组和ExAmen组的REE与预测REE的比值（REE:预测REE）分别为0.94±0.02、0.94±0.02和0.88±0.02。ExAmen组的REE:预测REE与能量缺乏一致。与其他组相比，ExAmen组的LogPYY、胃饥饿素、饮食认知抑制和瘦身驱动力升高。各组间GLP-1浓度相似。LogPYY与瘦身驱动力和REE/去脂体重相关。总之，患有功能性下丘脑性闭经的运动女性空腹PYY和胃饥饿素浓度升高，这两种胃肠肽可能作为该人群能量缺乏的替代指标。
