Florio Pasquale, Torres Paulo B, Torricelli Michela, Toti Paolo, Vale Wylie, Petraglia Felice
Department of Pediatrics, Obstetrics, and Reproductive Medicine, University of Siena, Siena, Italy.
Fertil Steril. 2006 Dec;86(6):1766-70. doi: 10.1016/j.fertnstert.2006.05.041. Epub 2006 Oct 30.
Urocortin II and urocortin III are recently identified corticotropin-releasing factor-related neuropeptides, and their endometrial expression throughout the menstrual cycle and in early pregnancy was evaluated in the present study by semiquantitative reverse transcriptase polymerase chain reaction and immunohistochemistry. The endometrial expression of urocortin II mRNA was significantly (P<.01) higher in the early proliferative phase of the menstrual cycle than in other phases and maternal decidua (MD), whereas that of urocortin III mRNA was higher (P<.01) in MD than in all other endometrial samples. Both peptides were immunolocalized in epithelial, stromal, and endothelial cells.
尿皮质素II和尿皮质素III是最近发现的与促肾上腺皮质激素释放因子相关的神经肽，在本研究中，我们通过半定量逆转录聚合酶链反应和免疫组织化学方法评估了它们在整个月经周期及妊娠早期子宫内膜中的表达情况。尿皮质素II mRNA在月经周期的增殖早期阶段的子宫内膜表达显著高于其他阶段及母体蜕膜（P<0.01），而尿皮质素III mRNA在母体蜕膜中的表达高于所有其他子宫内膜样本（P<0.01）。两种肽均在子宫内膜上皮细胞、基质细胞和内皮细胞中免疫定位。
