Hussein Ghazi, Nakagawa Takako, Goto Hirozo, Shimada Yutaka, Matsumoto Kinzo, Sankawa Ushio, Watanabe Hiroshi
International Research Center for Traditional Medicine, Toyama, Toyama Prefecture 939-8224, Japan.
Life Sci. 2007 Jan 16;80(6):522-9. doi: 10.1016/j.lfs.2006.09.041. Epub 2006 Oct 12.
Glucose and lipid metabolic parameters play crucial roles in metabolic syndrome and its major feature of insulin resistance. This study was designed to investigate whether dietary astaxanthin oil (ASX-O) has potential effects on metabolic syndrome features in an SHR/NDmcr-cp (cp/cp) rat model. Oral administration of ASX (50 mg/kg/day) for 22 weeks induced a significant reduction in arterial blood pressure in SHRcp. It also significantly reduced the fasting blood glucose level, homeostasis index of insulin resistance (HOMA-IR), and improved insulin sensitivity. The results also showed an improved adiponectin level, a significant increase in high-density lipoprotein cholesterol, a significant decrease in plasma levels of triglycerides, and non-esterified fatty acids. Additionally, ASX showed significant effects on the white adipose tissue by decreasing the size of the fat cells. These results suggest that ASX ameliorates insulin resistance by mechanisms involving the increase of glucose uptake, and by modulating the level of circulating lipid metabolites and adiponectin.
葡萄糖和脂质代谢参数在代谢综合征及其主要特征胰岛素抵抗中起着关键作用。本研究旨在调查膳食虾青素油（ASX - O）对SHR/NDmcr - cp（cp/cp）大鼠模型的代谢综合征特征是否具有潜在影响。在SHRcp中，连续22周口服ASX（50毫克/千克/天）可显著降低动脉血压。它还显著降低空腹血糖水平、胰岛素抵抗稳态模型评估指数（HOMA - IR），并改善胰岛素敏感性。结果还显示脂联素水平有所改善，高密度脂蛋白胆固醇显著增加，血浆甘油三酯和非酯化脂肪酸水平显著降低。此外，ASX通过减小脂肪细胞大小对白色脂肪组织产生显著影响。这些结果表明，ASX通过增加葡萄糖摄取以及调节循环脂质代谢物和脂联素水平的机制来改善胰岛素抵抗。
