Wiser Itay, Balicer Ran D, Cohen Dani
Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel-Aviv 69978, Israel.
Vaccine. 2007 Jan 22;25(6):976-84. doi: 10.1016/j.vaccine.2006.09.046. Epub 2006 Sep 22.
The threat of using variola virus in a bioterrorist attack urged different countries to renew the production of traditional vaccines and develop new generations of smallpox vaccines. Manufacturers try to combine smallpox vaccine past experience with technological advances in vaccine development to achieve protection similar to that of the traditional vaccines with a higher level of safety and fewer contraindications. In light of the reported immunogenicity and reactogenicity of the stockpiled smallpox vaccines employed in the last immunization campaigns of "first responders", we review recently accumulated data on the assessment of new smallpox vaccine candidates and discuss their role in possible vaccination policies.
在生物恐怖袭击中使用天花病毒的威胁促使不同国家恢复传统疫苗的生产，并研发新一代天花疫苗。制造商试图将天花疫苗的既往经验与疫苗研发的技术进步相结合，以实现与传统疫苗相似的保护效果，同时提高安全性并减少禁忌证。鉴于在“一线急救人员”的上次免疫接种活动中所使用的储备天花疫苗的免疫原性和反应原性报告，我们回顾了最近积累的关于新型天花疫苗候选物评估的数据，并讨论了它们在可能的疫苗接种政策中的作用。
