Ghio Andrew J, Funkhouser William, Pugh Christopher B, Winters Scot, Stonehuerner Jacqueline G, Mahar Annabelle M, Roggli Victor L
Clinical Research Branch, Human Studies Division, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA.
Toxicol Pathol. 2006;34(6):723-9. doi: 10.1080/01926230600932448.
Exposure to synthetic fibers with employment in textile mills can be associated with an elevated risk of interstitial lung disease (ILD). A mechanism of injury has not been determined. ILD can follow exposures to inorganic fibers (e.g., asbestos) which are associated with a mobilization of iron and catalysis of an oxidative stress. We describe 2 patients with ILD associated with exposure to synthetic textile fibers who demonstrated carbon-based ferruginous bodies suggesting an in vivo accumulation of iron by synthetic fibers after deposition in the lung. These iron-laden bodies varied from perfectly linear fibers to almost particulate matter. Linear structures were irregularly interrupted by deposition of iron-abundant material. The capacity of these synthetic fibers to complex iron and generate an oxidative stress is confirmed in vitro.
在纺织厂工作时接触合成纤维可能会增加患间质性肺病（ILD）的风险。损伤机制尚未确定。ILD可能继发于接触无机纤维（如石棉），无机纤维与铁的动员和氧化应激的催化有关。我们描述了2例与接触合成纺织纤维相关的ILD患者，他们表现出碳基含铁小体，提示合成纤维在肺内沉积后在体内蓄积铁。这些含铁体从完美的线性纤维到几乎呈颗粒状物质不等。线性结构被富含铁的物质沉积不规则地中断。这些合成纤维结合铁并产生氧化应激的能力在体外得到了证实。
