基于金黄色葡萄球菌表面蛋白的疫苗组装
Vaccine assembly from surface proteins of Staphylococcus aureus.
作者信息
Stranger-Jones Yukiko K, Bae Taeok, Schneewind Olaf
机构信息
Department of Microbiology, University of Chicago, 920 East 58th Street, Chicago, IL 60637, USA.
出版信息
Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16942-7. doi: 10.1073/pnas.0606863103. Epub 2006 Oct 30.
Abstract
Staphylococcus aureus is the most common cause of hospital-acquired infection. Because of the emergence of antibiotic-resistant strains, these infections represent a serious public health threat. To develop a broadly protective vaccine, we tested cell wall-anchored surface proteins of S. aureus as antigens in a murine model of abscess formation. Immunization with four antigens (IsdA, IsdB, SdrD, and SdrE) generated significant protective immunity that correlated with the induction of opsonophagocytic antibodies. When assembled into a combined vaccine, the four surface proteins afforded high levels of protection against invasive disease or lethal challenge with human clinical S. aureus isolates.
摘要
金黄色葡萄球菌是医院获得性感染最常见的病因。由于抗生素耐药菌株的出现，这些感染构成了严重的公共卫生威胁。为了研发一种具有广泛保护作用的疫苗，我们在小鼠脓肿形成模型中测试了金黄色葡萄球菌细胞壁锚定表面蛋白作为抗原的效果。用四种抗原（IsdA、IsdB、SdrD和SdrE）进行免疫可产生显著的保护性免疫，这与调理吞噬抗体的诱导相关。当组装成联合疫苗时，这四种表面蛋白对人类临床金黄色葡萄球菌分离株引起的侵袭性疾病或致死性攻击提供了高水平的保护。
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