Pflugfelder Stephen C
Ocular Surface Center, Department of Ophthalmology, Baylor College of Medicine, Houston, TX 77030, USA.
Ocul Surf. 2003 Jan;1(1):31-6. doi: 10.1016/s1542-0124(12)70005-8.
As tear secretion and tear clearance decrease in the dry eye, an inflammatory response is initiated on the ocular surface that appears to involve both soluble and cellular mediators. Although the traditional approach to treating dry eye is to hydrate and lubricate the ocular surface with artificial tears, symptoms and/or sight-threatening corneal disease may persist in some patients on such aqueous enhancement therapies. In these patients, treatment with anti-inflammatory agents, such as cyclosporin A, corticosteroids, tetracyclines, or autologous serum, may be considered. Results of studies investigating the use of these agents are discussed. During treatment, patients should be conscientiously monitored for adverse effects.
随着干眼症中泪液分泌和泪液清除减少，眼表会引发炎症反应，这似乎涉及可溶性介质和细胞介质。尽管治疗干眼症的传统方法是使用人工泪液使眼表水合和润滑，但在一些接受这种水性增强疗法的患者中，症状和/或威胁视力的角膜疾病可能仍然存在。对于这些患者，可以考虑使用抗炎药物进行治疗，如环孢素A、皮质类固醇、四环素或自体血清。本文讨论了研究这些药物使用情况的研究结果。在治疗期间，应认真监测患者的不良反应。
