Homma S, Nagamori S, Fujise K, Hasumura S, Sujino H, Matsuura T, Shimizu K, Niiya M, Kameda H
First Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.
Hum Cell. 1990 Jun;3(2):152-7.
A human hepatocellular carcinoma cell line, JHH-7, was established from resected liver tumor of a 53 year old male with hepatitis B virus infection. JHH-7 was composed of polygonal epithelial cells and functionally synthesized and secreted human albumin, AFP, CEA and ferritin. No HBsAg was detected in the culture supernatant of JHH-7 cells. Changes of secretion of AFP and CEA from JHH-7 cells after heat treatment was studied using a temperature gradient incubator. Secretion of AFP decreased along with the inhibition of cell proliferation by heat treatment. Secretion of CEA, however, did not decrease even though the cells were damaged.
