Al-Agha Osama M, Nicastri Anthony D
Department of Pathology, State University of New York Downstate Medical Center, 450 Clarkson Ave, Box 25, Brooklyn, NY 11203, USA.
Arch Pathol Lab Med. 2006 Nov;130(11):1725-30. doi: 10.5858/2006-130-1725-AILAKT.
Krukenberg tumor is an uncommon metastatic tumor of the ovary. This article provides an overview of the major pathologic manifestations of Krukenberg tumor, patient characteristics, clinical and laboratory features of the disease, prognostic factors, and current knowledge about its pathogenesis. Pathologists have to be familiar with the diagnostic histopathologic features of the tumor and its principal differential diagnoses. Awareness of the diagnostic manifestations of the tumor leads to the correct diagnosis and prevents tumor misclassification, thus avoiding improper clinical management. The article also addresses the potential clinical utility of serum CA 125 in patients with Krukenberg tumors. Prognosis of Krukenberg tumor is still very poor but our review of the literature reveals several factors that appear to have an impact on survival. There is no established treatment for Krukenberg tumors. A national registry and prospective studies are needed to set a therapeutic approach for Krukenberg tumors in the hope of improving the survival rate.
库肯勃瘤是一种罕见的卵巢转移性肿瘤。本文概述了库肯勃瘤的主要病理表现、患者特征、该疾病的临床和实验室特征、预后因素以及目前关于其发病机制的认识。病理学家必须熟悉该肿瘤的诊断性组织病理学特征及其主要鉴别诊断。了解该肿瘤的诊断表现有助于正确诊断并防止肿瘤误诊，从而避免不恰当的临床处理。本文还探讨了血清CA 125在库肯勃瘤患者中的潜在临床应用价值。库肯勃瘤的预后仍然很差，但我们对文献的综述揭示了几个似乎对生存有影响的因素。目前尚无针对库肯勃瘤的确立治疗方法。需要建立一个全国性登记系统并开展前瞻性研究，以制定针对库肯勃瘤的治疗方法，有望提高生存率。
