环氧化酶抑制剂芬布芬对克伦特罗诱导的大鼠心肌和骨骼肌肥大的影响。

Effects of the cyclo-oxygenase inhibitor, fenbufen, on clenbuterol-induced hypertrophy of cardiac and skeletal muscle of rats.

Palmer R M, Delday M I, McMillan D N, Noble B S, Bain P, Maltin C A

Rowett Research Institute, Bucksburn, Aberdeen.

Br J Pharmacol. 1990 Dec;101(4):835-8. doi: 10.1111/j.1476-5381.1990.tb14166.x.

When rats were fed with clenbuterol for 7 days skeletal muscle mass increased by 21% in the tonic soleus and phasic plantaris muscles and a 16% hypertrophy of the heart was also induced. Fenbufen, fed to rats for the same period, blocked the hypertrophy of the heart but not that of the skeletal muscles. 2. When feeding of fenbufen commenced 3 days before the administration of clenbuterol, plasma prosta-glandin F2 alpha (PGF2 alpha) was reduced by 79%; there was again no effect of fenbufen on clenbuterol-induced increases in the RNA or protein content of plantaris, nor in the increased area of fast or slow twitch fibres in the soleus. In the heart the clenbuterol-induced increases in the RNA (+21%) and protein content (+20%) were totally inhibited. 3. The effects of clenbuterol on heart muscle appear to be mediated by a cyclo-oxygenase metabolite of arachidonic acid whilst the effects on skeletal muscle are not.

给大鼠喂食克伦特罗7天后，比目鱼肌（慢肌）和跖肌（快肌）的骨骼肌质量增加了21%，同时还诱发了心脏16%的肥大。给大鼠同期喂食芬布芬，可抑制心脏肥大，但对骨骼肌肥大无影响。2. 在给予克伦特罗前3天开始喂食芬布芬，血浆前列腺素F2α（PGF2α）降低了79%；芬布芬对克伦特罗诱导的跖肌RNA或蛋白质含量增加以及比目鱼肌快肌或慢肌纤维面积增加均无影响。在心脏中，克伦特罗诱导的RNA含量增加（+21%）和蛋白质含量增加（+20%）被完全抑制。3. 克伦特罗对心肌的作用似乎是由花生四烯酸的环氧化酶代谢产物介导的，而对骨骼肌的作用则不是。

Effects of the cyclo-oxygenase inhibitor, fenbufen, on clenbuterol-induced hypertrophy of cardiac and skeletal muscle of rats.