McCue Robert E, Waheed Rubina, Urcuyo Leonel, Orendain Geraldine, Joseph Michel D, Charles Richard, Hasan Syed M
Department of Psychiatry, Wooodhull Medical and Mental Health Center, 760 Broadway, Brooklyn, New York 11206, USA.
Br J Psychiatry. 2006 Nov;189:433-40. doi: 10.1192/bjp.bp.105.019307.
There is little information on the comparative effectiveness of second-generation antipsychotic agents.
To determine if any of five second-generation antipsychotics or haloperidol is more effective in treating acutely ill patients with schizophrenia, schizoaffective disorder or schizophreniform disorder.
A sample of 327 newly admitted patients were randomised to open-label treatment with aripiprazole, haloperidol, olanzapine, quetiapine, risperidone or ziprasidone for a minimum of 3 weeks. Measures of effectiveness were improvement in mental status so that the patient no longer required acute in-patient care, and changes in Brief Psychiatric Rating Scale (BPRS) scores.
By the first measure, haloperidol (89%), olanzapine (92%) and risperidone (88%) were significantly more effective than aripiprazole (64%), quetiapine (64%) and ziprasidone (64%). Changes in BPRS ratings were not significant among treatments.
Haloperidol, olanzapine and risperidone are superior to aripiprazole, quetiapine and ziprasidone for the acute treatment of psychosis in hospitalised patients with schizophrenia, schizoaffective disorder or schizophreniform disorder.
关于第二代抗精神病药物的比较疗效的信息较少。
确定五种第二代抗精神病药物或氟哌啶醇中的任何一种在治疗急性发作的精神分裂症、分裂情感性障碍或精神分裂症样障碍患者时是否更有效。
327名新入院患者被随机分配接受阿立哌唑、氟哌啶醇、奥氮平、喹硫平、利培酮或齐拉西酮的开放标签治疗，为期至少3周。疗效指标为精神状态改善，使患者不再需要急性住院治疗，以及简明精神病评定量表（BPRS）评分的变化。
根据第一项指标，氟哌啶醇（89%）、奥氮平（92%）和利培酮（88%）比阿立哌唑（64%）、喹硫平（64%）和齐拉西酮（64%）显著更有效。各治疗组间BPRS评分变化无显著差异。
在住院的精神分裂症、分裂情感性障碍或精神分裂症样障碍患者的精神病急性治疗中，氟哌啶醇、奥氮平和利培酮优于阿立哌唑、喹硫平和齐拉西酮。
