Nakamura Seikou, Murakami Toshiyuki, Nakamura Junko, Kobayashi Hisanori, Matsuda Hisashi, Yoshikawa Masayuki
Kyoto Pharmaceutical University, Misasagi, Kyoto, Japan.
Chem Pharm Bull (Tokyo). 2006 Nov;54(11):1545-50. doi: 10.1248/cpb.54.1545.
Three new cucurbitane-type triterpene called karavilagenins A, B, and C and five new cucurbitane-type triterpene glycosides called karavilosides I, II, III, IV, and V were isolated from the dried fruit of Sri Lanka Momordica charantia L. (Cucurbitaceae) together with two known cucurbitane-type triterpenes, 19(R)-methoxy-5beta,19-epoxycucurbita-6,23-dien-3beta,25-diol and 5,19-epoxycucurbita-6,23-diene-3,25-diol, and nine known cucurbitane-type triterpene glycosides, goyaglycosides-b, -c, and -d, and momordicosides F1, F2, G, I, K, and L. The structures of karavilagenins and karavilosides were elucidated on the basis of chemical and physicochemical evidence.
从斯里兰卡苦瓜（葫芦科）的干燥果实中分离出三种新的葫芦烷型三萜，分别称为卡拉维拉苷元A、B和C，以及五种新的葫芦烷型三萜糖苷，分别称为卡拉维洛苷I、II、III、IV和V，同时还分离出两种已知的葫芦烷型三萜，19(R)-甲氧基-5β,19-环氧葫芦-6,23-二烯-3β,25-二醇和5,19-环氧葫芦-6,23-二烯-3,25-二醇，以及九种已知的葫芦烷型三萜糖苷，戈亚糖苷-b、-c和-d，和苦瓜苷F1、F2、G、I、K和L。基于化学和物理化学证据阐明了卡拉维拉苷元和卡拉维洛苷的结构。
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