Celik Ayla, Cavaş Tolga, Ergene-Gözükara Serap
Department of Biology, Faculty of Sciences and Letters, Mersin University, Ciftlikköy, 33342 Mersin, Turkey.
Mutagenesis. 2003 Sep;18(5):417-21. doi: 10.1093/mutage/geg022.
To study the effects of occupational exposure to petroleum derivates such as benzene, exfoliated buccal cells from 50 petrol station attendants and 50 age- and sex-matched control subjects were examined for micronucleus (MN) frequency. Frequencies of nuclear abnormalities (NA) other than micronuclei, such as binucleates, karyorrhexis and karyolysis, were also evaluated. Benzene exposure was ascertained by measuring urinary phenol levels. The mean urinary phenol level of station workers was found to be significantly higher than that of control subjects (P < 0.05). Analysis of buccal cells revealed that MN and NA frequencies in petrol station workers were significantly higher than in control subjects (P < 0.01) and also significantly related to smoking habit (P < 0.01). Our findings indicate that the petrol station workers are under risk of significant cytogenetic damage.
为研究职业性接触苯等石油衍生物的影响，对50名加油站工作人员以及50名年龄和性别匹配的对照者的脱落颊细胞进行了微核（MN）频率检测。还评估了除微核之外的其他核异常（NA）频率，如双核、核固缩和核溶解。通过测量尿酚水平确定苯暴露情况。发现加油站工作人员的平均尿酚水平显著高于对照者（P < 0.05）。颊细胞分析显示，加油站工作人员的微核和核异常频率显著高于对照者（P < 0.01），且也与吸烟习惯显著相关（P < 0.01）。我们的研究结果表明，加油站工作人员面临显著细胞遗传损伤的风险。
