巴西帕拉州圣塔伦市加油站工作人员职业暴露的遗传毒性效应。
Genotoxic effects of occupational exposure among gas station attendants in Santarem, Para, Brazil.
作者信息
Maciel Luan Aércio, Feitosa Samaroni Brelaz, Trolly Thais Sena, Sousa Albino Luciano
机构信息
Graduate Program in Biosciences, Universidade Federal do Oeste do Pará - Santarém (PA), Brazil.
Universidade Estadual do Pará - Santarém (PA), Brazil.
出版信息
Rev Bras Med Trab. 2020 Feb 12;17(2):247-253. doi: 10.5327/Z1679443520190382. eCollection 2019.
BACKGROUND
Gas station attendants are at high risk of poisoning due to continuous exposure to fuel fumes. Benzene, present in gasoline, is considered a carcinogen and harmful to the health of gas station attendants.
OBJECTIVE
To investigate genotoxic effects on exfoliated oral mucosa cells in association with occupational exposure among gas station attendants in Santarem, Para, Brazil, and to establish the rate of adherence to personal protective equipment (PPE).
METHODS
The results of the micronucleus test performed with oral mucosa cells stained by means of the Feulgen and Fast Green methods were compared between 126 exposed gas station attendants distributed across six groups and controls.
RESULTS
The frequency of micronuclei was higher among gas station attendants compared to the group not exposed to benzene (p<0.01). The frequency of micronuclei was significantly higher (p<0.01) among the gas station attendants who reported to drink alcohol compared to non-drinkers. None of the participants (0%) used PPE.
CONCLUSION
The frequency of micronuclei in exfoliated oral mucosa cells was higher among gas station attendants compared to controls; frequency was even higher for the gas station attendants who reported to consume alcohol often.
背景
加油站工作人员因持续接触燃油废气而面临高中毒风险。汽油中存在的苯被认为是一种致癌物，对加油站工作人员的健康有害。
目的
调查巴西帕拉州圣塔伦市加油站工作人员职业暴露与口腔黏膜脱落细胞遗传毒性效应之间的关系，并确定个人防护设备（PPE）的依从率。
方法
对126名分布在六组的暴露加油站工作人员和对照组进行比较，这些人员的口腔黏膜细胞采用福尔根和固绿方法染色后进行微核试验。
结果
与未接触苯的组相比，加油站工作人员的微核频率更高（p<0.01）。与不饮酒者相比，报告饮酒的加油站工作人员的微核频率显著更高（p<0.01）。没有参与者（0%）使用个人防护设备。
结论
与对照组相比，加油站工作人员口腔黏膜脱落细胞中的微核频率更高；报告经常饮酒的加油站工作人员的微核频率更高。
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