Tahara E, Haizuka S, Kodama T, Yamada A
Acta Pathol Jpn. 1975 Mar;25(2):161-77. doi: 10.1111/j.1440-1827.1975.tb00855.x.
Using advanced gastric adenocarcinoma and carcinoid as human material and gastric adenocarcinoma in rats induced by MNNG and in mice by localized X-irradiation of the stomach as experimental material, a pathological study was made on the relationship of gastric endocrine cells to gastric cancer. The results of the present study suggest that most of the endocrine cells in the cancer tissue are derived from the differentiation of cancer cells. Therefore, the following three may be given as the aformentioned relationship, that is, 1) carcinoid of endocrine cell origin, 2) endocrine cell carcinoma showing undifferentiated adenocarcinoma, and 3) endocrine cell cloning developed from the differentiation of cancer cell of adenocarcinoma. There is the possibility that most of 2) are of 3) origin and thus 2) and 3) should be discriminated from 1), having a functioning tumor in rare cases. The significance of reactive hyperplasia of endocrine cells in the non-metaplastic mucosa of the stomach around cancer and atypical epithelium is not yet determined, but that of EC cell seems at least to be related with the development of intestinal metaplasia in the gastric mucosa.
以进展期胃腺癌和类癌为人体材料，以MNNG诱导的大鼠胃腺癌和胃局部X线照射诱导的小鼠胃腺癌为实验材料，对胃内分泌细胞与胃癌的关系进行了病理学研究。本研究结果提示，癌组织中的大多数内分泌细胞来源于癌细胞的分化。因此，上述关系可归纳为以下三种情况：即1）内分泌细胞起源的类癌；2）表现为未分化腺癌的内分泌细胞癌；3）由腺癌癌细胞分化形成的内分泌细胞克隆。2）中的大多数有可能起源于3），因此2）和3）应与1）相鉴别，1）在罕见情况下为功能性肿瘤。癌周非化生胃黏膜及非典型上皮中内分泌细胞反应性增生的意义尚未明确，但EC细胞的意义似乎至少与胃黏膜肠化生的发生有关。
