Shimoda T, Tanoue S, Ikegami M, Fujii Y, Muroya T, Ishikawa E
Acta Pathol Jpn. 1983 Nov;33(6):1259-67. doi: 10.1111/j.1440-1827.1983.tb02171.x.
The present study includes a histopathological and immunohistochemical study of 4 cases of diffuse hyperplasia of gastric argyrophil cells. The mode of proliferation of these cells and the production of hormone by these cells have been documented. The distribution of microacinar nests composed of argyrophil cells was thought to be related to chronic gastritis in which there are atrophy of mucosa and intestinal metaplasia. In the case in which these nests were found only in the corpus ventriculi, there was intestinal metaplasia throughout the stomach. On the other hand, in the case in which these nests appeared only in the pyloric area, atrophy of the mucosa with mild intestinal metaplasia was observed only in the pyloric area. The microacinar nests composed of argyrophil cells were distributed in the deep mucosa at the basal portion of the glands in the area with intestinal metaplasia. Serial sections revealed a sprout composed of argyrophil cells budding from the gland with intestinal metaplastic changes. The sprout buds out from the growth zone of glands with intestinal metaplasia and then becomes isolated and gives rise to reactive hyperplasia. The peptide hormone contained in these cells differs according to the mucosal environments. Cells containing gastrin were observed in the pyloric area, but not in the corpus ventriculi where there was marked intestinal metaplasia. The cells in this area were assumed to contain other hormones.
本研究包括对4例胃嗜银细胞弥漫性增生的组织病理学和免疫组织化学研究。记录了这些细胞的增殖方式及其激素分泌情况。由嗜银细胞组成的微腺泡巢的分布被认为与存在黏膜萎缩和肠化生的慢性胃炎有关。在仅在胃体部发现这些巢的病例中，整个胃均有肠化生。另一方面，在仅在幽门区出现这些巢的病例中，仅在幽门区观察到伴有轻度肠化生的黏膜萎缩。由嗜银细胞组成的微腺泡巢分布在肠化生区域腺体基部的深层黏膜中。连续切片显示，在发生肠化生改变的腺体中有一个由嗜银细胞形成的芽。该芽从发生肠化生的腺体生长区长出，然后分离并引起反应性增生。这些细胞所含的肽类激素因黏膜环境而异。在幽门区观察到含有胃泌素的细胞，但在有明显肠化生的胃体部未观察到。该区域的细胞被认为含有其他激素。
