卡兰索苷A - C，来自细叶落地生根地上部分的新型细胞毒性蟾蜍二烯羟酸内酯。
Kalanchosides A-C, new cytotoxic bufadienolides from the aerial parts of Kalanchoe gracilis.
作者信息
Wu Pei-Lin, Hsu Yu-Lin, Wu Tian-Shung, Bastow K F, Lee Kuo-Hsiung
机构信息
Department of Cosmetic Science, Chung Hwa College of Medical Technology, Tainan 717, Taiwan, Republic of China.
出版信息
Org Lett. 2006 Nov 9;8(23):5207-10. doi: 10.1021/ol061873m.
[Structure: see text] Three new compounds, kalanchosides A-C (1-3), as well as five known compounds, were isolated from the aerial parts of Kalanchoe gracilis. The compound structures were determined by spectroscopic methods. All eight isolated compounds showed significant cytotoxic activity against a panel of human tumor cell lines, with potency reaching the nanomolar range. However, only bryophyllin B (8) inhibited HIV replication in H9 lymphocyte cells.
[结构：见正文] 从细叶落地生根的地上部分分离出三种新化合物，落地生根苷A-C（1-3）以及五种已知化合物。通过光谱方法确定了化合物的结构。所有八种分离出的化合物对一组人类肿瘤细胞系均表现出显著的细胞毒性活性，效力达到纳摩尔范围。然而，只有玉海棠素B（8）能抑制H9淋巴细胞中的HIV复制。
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