（±）-clusianone的合成：通过双环[3.3.1]壬烷-2,4,9-三酮的烯醇醚衍生物的区域选择性锂化进行高产率的桥头和二酮取代。
Synthesis of (+/-)-clusianone: high-yielding bridgehead and diketone substitutions by regioselective lithiation of enol ether derivatives of bicyclo[3.3.1]nonane-2,4,9-triones.
作者信息
Rodeschini Vincent, Ahmad Nadia M, Simpkins Nigel S
机构信息
School of Chemistry, The University of Nottingham, University Park, Nottingham, NG7 2RD UK.
出版信息
Org Lett. 2006 Nov 9;8(23):5283-5. doi: 10.1021/ol0620592.
PMID:17078698
Abstract
[Structure: see text] A concise synthesis of the polyprenylated acylphloroglucinol natural product, clusianone, in racemic form, is described. An Effenburger cyclization generated a core bicyclo[3.3.1]nonane-trione structure, which was then elaborated by means of regioselective lithiation reactions.
摘要
[结构：见正文] 报道了聚异戊二烯基酰基间苯三酚天然产物clusianone外消旋体的简洁合成方法。埃芬伯格环化反应生成了一个核心的双环[3.3.1]壬烷-三酮结构，然后通过区域选择性锂化反应对其进行进一步修饰。
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