人类免疫缺陷病毒1型（HIV-1）跨膜糖蛋白的连续表位以及人血清对代表各种HIV-1分离株的合成肽的反应性。
Continuous epitopes of the human immunodeficiency virus type 1 (HIV-1) transmembrane glycoprotein and reactivity of human sera to synthetic peptides representing various HIV-1 isolates.
作者信息
Horal P, Svennerholm B, Jeansson S, Rymo L, Hall W W, Vahlne A
机构信息
Department of Clinical Virology, University of Göteborg, Sweden.
出版信息
J Virol. 1991 May;65(5):2718-23. doi: 10.1128/JVI.65.5.2718-2723.1991.
Abstract
Immunoreactive regions of human immunodeficiency virus type 1 (HIV-1) gp41 were mapped by reacting HIV-1 antibody-positive human sera with overlapping synthetic peptides which covered the transmembrane protein. Three immunoreactive domains were identified, and five different and partially overlapping epitopes recognized by HIV-1-positive human sera were found within one immunodominant region. The effect on antibody recognition after single amino acid substitutions within one defined epitope was also studied. The reactivity of various HIV-1-positive sera to synthetic peptides with amino acid substitutions representing known isolates suggests an important substitution in the major epitope of African HIV-1 strains.
摘要
通过用覆盖跨膜蛋白的重叠合成肽与人类免疫缺陷病毒1型（HIV-1）抗体阳性的人血清反应，绘制了HIV-1 gp41的免疫反应区域。鉴定出三个免疫反应结构域，并且在一个免疫显性区域内发现了HIV-1阳性人血清识别的五个不同且部分重叠的表位。还研究了在一个确定表位内单个氨基酸取代后对抗体识别的影响。各种HIV-1阳性血清对具有代表已知分离株的氨基酸取代的合成肽的反应性表明非洲HIV-1毒株主要表位中有一个重要取代。
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