Latefi Nazlie S, Colman David R
Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, BT-105, H3A2B4, Montreal, QC, Canada.
Neurochem Res. 2007 Feb;32(2):303-10. doi: 10.1007/s11064-006-9181-0. Epub 2006 Nov 2.
Although processes leading up to the point of synapse formation are fairly well understood, the precise sequence of events in which the membranes of two separate cells "lock in" to form a mature synaptic junctional complex is poorly understood. A careful study of the molecules operating at the synapse indicates that their roles are more multifarious than once imagined. In this review we posit that the synapse is a functional organelle with poorly defined boundaries and a complex biochemistry. The role of adhesion molecules, including the integration of their signaling and adhesive properties in the context of synaptic activity is discussed.
尽管突触形成之前的过程已得到相当充分的理解，但对于两个独立细胞的膜“锁定”形成成熟突触连接复合体的精确事件序列却知之甚少。对在突触处起作用的分子进行的仔细研究表明，它们的作用比曾经想象的更加多种多样。在本综述中，我们假定突触是一种功能细胞器，其边界定义不清且具有复杂的生物化学性质。文中讨论了黏附分子的作用，包括它们在突触活动背景下信号传导和黏附特性的整合。
