[一种用于定量血液中丙泊酚的气相色谱-质谱分析法的开发]
[Development of a gas chromatography-mass spectrometry method for the quantification of propofol in blood].
作者信息
Zhu You-Jiang, Ding Xuan-Kun
机构信息
The people's Procuratorate of Huzhou, Huzhou 313000, China.
出版信息
Fa Yi Xue Za Zhi. 2006 Aug 15;22(4):313-4.
OBJECTIVE
A rapid and selective method has been developed for the determination of propofol in blood by gas chromatography-mass spectrometry (GC-MS).
METHODS
The blood was extrasted with the solution of internal standard, the extracted residue was analyzed by gas chromatography-mass spectrometry using selected-ion monitoring mode.
RESULTS
The linear range was 0.1-10 microg/mL. The coefficient(R2) was 0.993 1. The detection limit was 0.05 microg/mL.
CONCLUSION
The method is simple and rapid, offering superior sensitivity and selectivity for propofol. The method can be used successfully during clinical and forensic toxicology.
目的
已开发出一种通过气相色谱-质谱联用（GC-MS）快速、选择性地测定血液中丙泊酚的方法。
方法
血液用内标溶液萃取，萃取残渣采用气相色谱-质谱联用的选择离子监测模式进行分析。
结果
线性范围为0.1 - 10微克/毫升。相关系数（R2）为0.993 1。检测限为0.05微克/毫升。
结论
该方法简单快速，对丙泊酚具有卓越的灵敏度和选择性。该方法可成功应用于临床和法医毒理学。
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