Gas chromatography-mass spectrometric assay for propofol in cerebrospinal fluid of traumatic brain patients.
作者信息
Peeters Mariska Y M, Kuiper Hiltjo, Greijdanus Ben, van der Naalt Joukje, Knibbe Catherijne A J, Uges Donald R A
机构信息
Department of Clinical Pharmacy, St. Antonius Hospital, P.O. Box 2500, 3430 EM Nieuwegein, The Netherlands.
出版信息
J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jun 1;852(1-2):635-9. doi: 10.1016/j.jchromb.2007.01.001. Epub 2007 Jan 10.
A sensitive gas chromatography-mass spectrometry method for measuring propofol in cerebrospinal fluid is described, validated and applied to four patients after traumatic brain injury. The limit of quantitation was 2 microg/L using a volume of 0.5 mL. The inter- and intra-assay coefficients of variation were 5.9 and 5.1%, respectively. The assay covers the linear concentration range of 2-50 microg/L, which is relevant in clinical pharmacokinetic studies when propofol is used in the Intensive Care Unit as a sedative agent or to lower the intracranial pressure.
Zotero 插件