Xu Jinzhong, Takasaki Azusa, Kobayashi Hisayoshi, Oda Taiko, Yamada Junko, Mangindaan Remy E P, Ukai Kazuyo, Nagai Hiroshi, Namikoshi Michio
Department of Ocean Sciences, Tokyo University of Marine Science and Technology, Minato-ku, Tokyo 108-8477, Japan.
J Antibiot (Tokyo). 2006 Aug;59(8):451-5. doi: 10.1038/ja.2006.63.
Three new macrocyclic trichothecenes, named 12'-hydroxyroridin E (1), roridin Q (2), and 2',3'deoxyroritoxin D (3), were isolated from the marine-derived fungus Myrothecium roridum TUF 98F42, and a new macrocyclic trichothecene, named roridin R (4), was isolated from Myrothecium sp. TUF 02F6 together with roridins A and H and isororidin E. The structures of new compounds were determined on the basis of their spectral data. Compound 2 possessed a unique ether moiety at the 13' position of 1. Compound 4 was a 2',3'-dihydro-2'-hydroxy derivative of roridin H. The IC50 values of compounds 1, 2, and 4 against the murine leukemia cell line L1210 were 0.19, 31.2, and 0.45 microM, respectively. Compound 3 showed antiyeast activity to Saccharomyces cerevisiae at 1 microg/disc (inhibition zone: 12.2 mm), which was about 10 time more active than roritoxin D (10.2 mm at 10 microg/disc).
从海洋来源的真菌轮枝霉Myrothecium roridum TUF 98F42中分离出三种新的大环单端孢霉烯，分别命名为12'-羟基洛里丁E（1）、洛里丁Q（2）和2',3'-脱氧洛里毒素D（3）；从轮枝霉Myrothecium sp. TUF 02F6中分离出一种新的大环单端孢霉烯，命名为洛里丁R（4），同时还分离出了洛里丁A、H和异洛里丁E。新化合物的结构通过光谱数据确定。化合物2在1的13'位具有独特的醚部分。化合物4是洛里丁H的2',3'-二氢-2'-羟基衍生物。化合物1、2和4对小鼠白血病细胞系L1210的IC50值分别为0.19、31.2和0.45 microM。化合物3在1 microg/圆片时对酿酒酵母显示出抗酵母活性（抑菌圈：12.2 mm），其活性约为洛里毒素D（10 microg/圆片时为10.2 mm）的10倍。
