从两株海洋来源的漆斑菌属真菌中分离得到的四种新型大环单端孢霉烯族毒素。

Four new macrocyclic trichothecenes from two strains of marine-derived fungi of the genus Myrothecium.

作者信息

Xu Jinzhong, Takasaki Azusa, Kobayashi Hisayoshi, Oda Taiko, Yamada Junko, Mangindaan Remy E P, Ukai Kazuyo, Nagai Hiroshi, Namikoshi Michio

机构信息

Department of Ocean Sciences, Tokyo University of Marine Science and Technology, Minato-ku, Tokyo 108-8477, Japan.

出版信息

J Antibiot (Tokyo). 2006 Aug;59(8):451-5. doi: 10.1038/ja.2006.63.

DOI:10.1038/ja.2006.63

PMID:17080680

Abstract

Three new macrocyclic trichothecenes, named 12'-hydroxyroridin E (1), roridin Q (2), and 2',3'deoxyroritoxin D (3), were isolated from the marine-derived fungus Myrothecium roridum TUF 98F42, and a new macrocyclic trichothecene, named roridin R (4), was isolated from Myrothecium sp. TUF 02F6 together with roridins A and H and isororidin E. The structures of new compounds were determined on the basis of their spectral data. Compound 2 possessed a unique ether moiety at the 13' position of 1. Compound 4 was a 2',3'-dihydro-2'-hydroxy derivative of roridin H. The IC50 values of compounds 1, 2, and 4 against the murine leukemia cell line L1210 were 0.19, 31.2, and 0.45 microM, respectively. Compound 3 showed antiyeast activity to Saccharomyces cerevisiae at 1 microg/disc (inhibition zone: 12.2 mm), which was about 10 time more active than roritoxin D (10.2 mm at 10 microg/disc).

摘要

从海洋来源的真菌轮枝霉Myrothecium roridum TUF 98F42中分离出三种新的大环单端孢霉烯，分别命名为12'-羟基洛里丁E（1）、洛里丁Q（2）和2',3'-脱氧洛里毒素D（3）；从轮枝霉Myrothecium sp. TUF 02F6中分离出一种新的大环单端孢霉烯，命名为洛里丁R（4），同时还分离出了洛里丁A、H和异洛里丁E。新化合物的结构通过光谱数据确定。化合物2在1的13'位具有独特的醚部分。化合物4是洛里丁H的2',3'-二氢-2'-羟基衍生物。化合物1、2和4对小鼠白血病细胞系L1210的IC50值分别为0.19、31.2和0.45 microM。化合物3在1 microg/圆片时对酿酒酵母显示出抗酵母活性（抑菌圈：12.2 mm），其活性约为洛里毒素D（10 microg/圆片时为10.2 mm）的10倍。